A 50µm Pitch, 1120-Channel, 20kHz Frame Rate Microelectrode Array for Slice Recording

Ben Johnson; Shane T. Peace; Thomas A. Cleland; Alyosha Molnar

doi:10.1109/BioCAS.2013.6679651

A 50µm Pitch, 1120-Channel, 20kHz Frame Rate Microelectrode Array for Slice Recording

Ben Johnson
, Shane T. Peace
, Thomas A. Cleland
, Alyosha Molnar

Cornell University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

17 Scopus citations

Abstract

We present a 1,120 channel active microelectrode array with 50µm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3 µ Vrms with tunable high- and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.

Original language	American English
Title of host publication	2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)
DOIs	https://doi.org/10.1109/BioCAS.2013.6679651
State	Published - 2013
Externally published	Yes

EGS Disciplines

Electrical and Computer Engineering

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10.1109/BioCAS.2013.6679651License: Unspecified

Cite this

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title = "A 50µm Pitch, 1120-Channel, 20kHz Frame Rate Microelectrode Array for Slice Recording",

abstract = " We present a 1,120 channel active microelectrode array with 50µm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3 µ Vrms with tunable high- and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.",

author = "Ben Johnson and Peace, \{Shane T.\} and Cleland, \{Thomas A.\} and Alyosha Molnar",

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doi = "10.1109/BioCAS.2013.6679651",

language = "American English",

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AU - Johnson, Ben

AU - Peace, Shane T.

AU - Cleland, Thomas A.

AU - Molnar, Alyosha

N1 - We present a 1,120 channel active microelectrode array with 50μm pitch recording sites for direct recording of neural slices. Every sensor site has a front

PY - 2013

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N2 - We present a 1,120 channel active microelectrode array with 50µm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3 µ Vrms with tunable high- and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.

AB - We present a 1,120 channel active microelectrode array with 50µm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3 µ Vrms with tunable high- and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.

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M3 - Chapter

BT - 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

ER -

A 50µm Pitch, 1120-Channel, 20kHz Frame Rate Microelectrode Array for Slice Recording

Abstract

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