A clocked DNA-based replicator

Bernard Yurke; David Zhang

doi:10.1007/11493785_38

A clocked DNA-based replicator

Bernard Yurke, David Zhang

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

A stepped replicator is described that uses the energy of hybridization to pry the product from the template in order to prevent product inhibition of replication. Toehold-mediated strand displacement is used to reset the system to its initial state after a round of replication. It is argued that the formation of dimers between structures in the process of replicating should not be able to form and, consequently, the system should exhibit exponential growth.

Original language	English
Pages (from-to)	445-457
Number of pages	13
Journal	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	3384
DOIs	https://doi.org/10.1007/11493785_38
State	Published - 2005
Externally published	Yes
Event	10th International Workshop on DNA Computing, DNA 10 - Milan, Italy Duration: 7 Jun 2004 → 10 Jun 2004

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10.1007/11493785_38

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title = "A clocked DNA-based replicator",

abstract = "A stepped replicator is described that uses the energy of hybridization to pry the product from the template in order to prevent product inhibition of replication. Toehold-mediated strand displacement is used to reset the system to its initial state after a round of replication. It is argued that the formation of dimers between structures in the process of replicating should not be able to form and, consequently, the system should exhibit exponential growth.",

author = "Bernard Yurke and David Zhang",

year = "2005",

doi = "10.1007/11493785_38",

language = "English",

volume = "3384",

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note = "10th International Workshop on DNA Computing, DNA 10 ; Conference date: 07-06-2004 Through 10-06-2004",

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AU - Yurke, Bernard

AU - Zhang, David

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AB - A stepped replicator is described that uses the energy of hybridization to pry the product from the template in order to prevent product inhibition of replication. Toehold-mediated strand displacement is used to reset the system to its initial state after a round of replication. It is argued that the formation of dimers between structures in the process of replicating should not be able to form and, consequently, the system should exhibit exponential growth.

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DO - 10.1007/11493785_38

M3 - Conference article

AN - SCOPUS:24144457267

SN - 0302-9743

VL - 3384

SP - 445

EP - 457

JO - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

JF - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

T2 - 10th International Workshop on DNA Computing, DNA 10

Y2 - 7 June 2004 through 10 June 2004

ER -

A clocked DNA-based replicator

Abstract

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