A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker; Scott T. Phillips

doi:10.1021/ja108347d

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker, Scott T. Phillips

Micron School of Materials Science and Engineering

Pennsylvania State University

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

Original language	English
Pages (from-to)	5170-5173
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	14
DOIs	https://doi.org/10.1021/ja108347d
State	Published - 13 Apr 2011

Access to Document

10.1021/ja108347d

Cite this

@article{854a809b91134b63a4d5836670fbbc61,

title = "A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)",

abstract = "A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.",

author = "Baker, {Matthew S.} and Phillips, {Scott T.}",

year = "2011",

month = apr,

day = "13",

doi = "10.1021/ja108347d",

language = "English",

volume = "133",

pages = "5170--5173",

number = "14",

}

TY - JOUR

T1 - A two-component small molecule system for activity-based detection and signal amplification

T2 - Application to the visual detection of threshold levels of Pd(II)

AU - Baker, Matthew S.

AU - Phillips, Scott T.

PY - 2011/4/13

Y1 - 2011/4/13

N2 - A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

AB - A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

UR - http://www.scopus.com/inward/record.url?scp=79953690843&partnerID=8YFLogxK

U2 - 10.1021/ja108347d

DO - 10.1021/ja108347d

M3 - Article

C2 - 21425777

AN - SCOPUS:79953690843

SN - 0002-7863

VL - 133

SP - 5170

EP - 5173

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 14

ER -

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Abstract

Access to Document

Other files and links

Fingerprint

Cite this