A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker; Scott T. Phillips

doi:10.1021/ja108347d

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Matthew S. Baker
, Scott T. Phillips

Micron School of Materials Science and Engineering

Pennsylvania State University

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

Original language	English
Pages (from-to)	5170-5173
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	14
DOIs	https://doi.org/10.1021/ja108347d
State	Published - 13 Apr 2011

Keywords

Palladium/analysis
Limit of Detection
Temperature
Colorimetry
Chemistry Techniques, Analytical/instrumentation
Indicators and Reagents/chemistry

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10.1021/ja108347d

Cite this

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title = "A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)",

abstract = "A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.",

keywords = "Palladium/analysis, Limit of Detection, Temperature, Colorimetry, Chemistry Techniques, Analytical/instrumentation, Indicators and Reagents/chemistry",

author = "Baker, \{Matthew S.\} and Phillips, \{Scott T.\}",

note = "{\textcopyright} 2011 American Chemical Society",

year = "2011",

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doi = "10.1021/ja108347d",

language = "English",

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T2 - Application to the visual detection of threshold levels of Pd(II)

AU - Baker, Matthew S.

AU - Phillips, Scott T.

PY - 2011/4/13

Y1 - 2011/4/13

N2 - A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

AB - A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

KW - Palladium/analysis

KW - Limit of Detection

KW - Temperature

KW - Colorimetry

KW - Chemistry Techniques, Analytical/instrumentation

KW - Indicators and Reagents/chemistry

UR - https://www.scopus.com/pages/publications/79953690843

U2 - 10.1021/ja108347d

DO - 10.1021/ja108347d

M3 - Article

C2 - 21425777

AN - SCOPUS:79953690843

SN - 0002-7863

VL - 133

SP - 5170

EP - 5173

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 14

ER -

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Abstract

Keywords

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