TY - GEN
T1 - Absent sequences
T2 - Pacific Symposium on Biocomputing, PSB 2007
AU - Hampikian, Greg
AU - Andersen, Tim
PY - 2007
Y1 - 2007
N2 - We describe a new publicly available algorithm for identifying absent sequences, and demonstrate its use by listing the smallest oligomers not found in the human genome (human nullomers), and those not found in any reported genome or GenBank sequence (primes). These absent sequences define the maximum set of potentially lethal oligomers. They also provide a rational basis for choosing artificial DNA sequences for molecular barcodes, show promise for species identification and environmental characterization based on absence, and identify potential targets for therapeutic intervention and suicide markers.
AB - We describe a new publicly available algorithm for identifying absent sequences, and demonstrate its use by listing the smallest oligomers not found in the human genome (human nullomers), and those not found in any reported genome or GenBank sequence (primes). These absent sequences define the maximum set of potentially lethal oligomers. They also provide a rational basis for choosing artificial DNA sequences for molecular barcodes, show promise for species identification and environmental characterization based on absence, and identify potential targets for therapeutic intervention and suicide markers.
UR - http://www.scopus.com/inward/record.url?scp=34748827343&partnerID=8YFLogxK
M3 - Conference contribution
C2 - 17990505
AN - SCOPUS:34748827343
SN - 9812704175
SN - 9789812704177
T3 - Pacific Symposium on Biocomputing 2007, PSB 2007
SP - 355
EP - 366
BT - Pacific Symposium on Biocomputing 2007, PSB 2007
Y2 - 3 January 2007 through 7 January 2007
ER -
