TY - JOUR
T1 - Alkylfurans
T2 - Effects of alkyl side-chain length on insecticidal activity
AU - Rodriguez-Saona, Cesar R.
AU - Maynard, David F.
AU - Phillips, Scott
AU - Trumble, John T.
PY - 1999/1
Y1 - 1999/1
N2 - The insecticidal activity of five alkylfurans against the generalist insect herbivore beet armyworm, Spodoptera exigua, was examined. Two naturally occurring compounds, the avocadofurans 2-(pentadecyl)furan (1) and 2-(heptadecyl)furan (2), previously isolated from specialized avocado idioblast oil cells, and three homologues, 2-(tetradecyl)furan (3), 2- (hexadecyl)furan (4), and 2-(octadecyl)furan (5), were synthesized. Bioassays of a1kylfurans 1-5 using a 9-day diet-incorporation initiated with neonates showed that all a1kylfurans tested significantly increased S. exigua larval mortality and reduced larval weights, with maximal biological activity detected among the naturally occurring alkylfurans 1 and 2.
AB - The insecticidal activity of five alkylfurans against the generalist insect herbivore beet armyworm, Spodoptera exigua, was examined. Two naturally occurring compounds, the avocadofurans 2-(pentadecyl)furan (1) and 2-(heptadecyl)furan (2), previously isolated from specialized avocado idioblast oil cells, and three homologues, 2-(tetradecyl)furan (3), 2- (hexadecyl)furan (4), and 2-(octadecyl)furan (5), were synthesized. Bioassays of a1kylfurans 1-5 using a 9-day diet-incorporation initiated with neonates showed that all a1kylfurans tested significantly increased S. exigua larval mortality and reduced larval weights, with maximal biological activity detected among the naturally occurring alkylfurans 1 and 2.
KW - Animals
KW - Furans/chemistry
KW - Insecticides/chemistry
KW - Spodoptera
KW - Structure-Activity Relationship
UR - http://www.scopus.com/inward/record.url?scp=0032939446&partnerID=8YFLogxK
U2 - 10.1021/np980340m
DO - 10.1021/np980340m
M3 - Article
C2 - 9917319
AN - SCOPUS:0032939446
SN - 0163-3864
VL - 62
SP - 191
EP - 193
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -