Analysis and Characterization of Urea-based Compounds Targeting Escherichia coli Methylthioadenosine Nucleosidase (MTN).

Rylee Samander; Christina Lee; Dylan Olson; Necia M. Hunter; John H. Thurston; Ken Cornell

Analysis and Characterization of Urea-based Compounds Targeting Escherichia coli Methylthioadenosine Nucleosidase (MTN).

Rylee Samander, Christina Lee, Dylan Olson, Necia M. Hunter, John H. Thurston, Ken Cornell

Chemistry Department

Research output: Contribution to conference › Presentation

Abstract

Antibiotic resistant infections continue to be a major health concern worldwide, and the development of new antibiotic drugs is an important step towards addressing this issue. One potential drug target is methylthioadenosine nucleosidase (MTN), an important metabolic enzyme in both parasites and bacteria. This study focused on the characterization and analysis of inhibitory activity of several novel urea-based compounds against Escherichia coli MTN. In an effort to develop drugs with a high specificity and activity, these compounds were designed based on the structure of several other MTN inhibitors that have previously been described. Inhibitor characterization included NMR and IR spectroscopy, along with extinction coefficient analysis and Ki value for bacterial MTN.

Original language	American English
State	Published - 12 Jul 2015

EGS Disciplines

Biochemistry
Enzymes and Coenzymes
Immunology and Infectious Disease
Other Chemicals and Drugs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@conference{778ffc17e64949f183351cf3aba4cc78,

title = "Analysis and Characterization of Urea-based Compounds Targeting Escherichia coli Methylthioadenosine Nucleosidase (MTN).",

abstract = " Antibiotic resistant infections continue to be a major health concern worldwide, and the development of new antibiotic drugs is an important step towards addressing this issue. One potential drug target is methylthioadenosine nucleosidase (MTN), an important metabolic enzyme in both parasites and bacteria. This study focused on the characterization and analysis of inhibitory activity of several novel urea-based compounds against Escherichia coli MTN. In an effort to develop drugs with a high specificity and activity, these compounds were designed based on the structure of several other MTN inhibitors that have previously been described. Inhibitor characterization included NMR and IR spectroscopy, along with extinction coefficient analysis and Ki value for bacterial MTN.",

author = "Rylee Samander and Christina Lee and Dylan Olson and Hunter, {Necia M.} and Thurston, {John H.} and Ken Cornell",

year = "2015",

month = jul,

day = "12",

language = "American English",

}

TY - CONF

T1 - Analysis and Characterization of Urea-based Compounds Targeting Escherichia coli Methylthioadenosine Nucleosidase (MTN).

AU - Samander, Rylee

AU - Lee, Christina

AU - Olson, Dylan

AU - Hunter, Necia M.

AU - Thurston, John H.

AU - Cornell, Ken

PY - 2015/7/12

Y1 - 2015/7/12

N2 - Antibiotic resistant infections continue to be a major health concern worldwide, and the development of new antibiotic drugs is an important step towards addressing this issue. One potential drug target is methylthioadenosine nucleosidase (MTN), an important metabolic enzyme in both parasites and bacteria. This study focused on the characterization and analysis of inhibitory activity of several novel urea-based compounds against Escherichia coli MTN. In an effort to develop drugs with a high specificity and activity, these compounds were designed based on the structure of several other MTN inhibitors that have previously been described. Inhibitor characterization included NMR and IR spectroscopy, along with extinction coefficient analysis and Ki value for bacterial MTN.

AB - Antibiotic resistant infections continue to be a major health concern worldwide, and the development of new antibiotic drugs is an important step towards addressing this issue. One potential drug target is methylthioadenosine nucleosidase (MTN), an important metabolic enzyme in both parasites and bacteria. This study focused on the characterization and analysis of inhibitory activity of several novel urea-based compounds against Escherichia coli MTN. In an effort to develop drugs with a high specificity and activity, these compounds were designed based on the structure of several other MTN inhibitors that have previously been described. Inhibitor characterization included NMR and IR spectroscopy, along with extinction coefficient analysis and Ki value for bacterial MTN.

M3 - Presentation

ER -

Analysis and Characterization of Urea-based Compounds Targeting Escherichia coli Methylthioadenosine Nucleosidase (MTN).

Abstract

EGS Disciplines

UN SDGs

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