Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children with Nontuberculous Mycobacterial Infection

Tiffany A. Claeys; Oscar Rosas Mejia; Samuel Marshall; Jason A. Jarzembowski; Don Hayes; Natalie M. Hull; Namal P.M. Liyanage; Robert H. Chun; Cecille G. Sulman; Anna R. Huppler; Richard T. Robinson

doi:10.1093/infdis/jiz371

Attenuation of Helper T Cell Capacity for T_H1 and T_H17 Differentiation in Children with Nontuberculous Mycobacterial Infection

Tiffany A. Claeys, Oscar Rosas Mejia, Samuel Marshall, Jason A. Jarzembowski, Don Hayes, Natalie M. Hull, Namal P.M. Liyanage, Robert H. Chun, Cecille G. Sulman, Anna R. Huppler, Richard T. Robinson

Civil Engineering Department

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4 Scopus citations

Abstract

Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (T_H) cells in functional assays of T_H1/T_H17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating T_H cells from infected children were attenuated in their T_H1/T_H17 differentiation capacity and expressed less interferon γand interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein T_H1/T_H17 differentiation is attenuated in NTM-infected children.

Original language	English
Pages (from-to)	1843-1847
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	220
Issue number	11
DOIs	https://doi.org/10.1093/infdis/jiz371
State	Published - 22 Oct 2019

Keywords

Children
Immune
Mycobacteria
Nontuberculous
NTM
pediatric
T1 and T17 cells

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10.1093/infdis/jiz371

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Claeys, T. A., Rosas Mejia, O., Marshall, S., Jarzembowski, J. A., Hayes, D., Hull, N. M., Liyanage, N. P. M., Chun, R. H., Sulman, C. G., Huppler, A. R., & Robinson, R. T. (2019). Attenuation of Helper T Cell Capacity for T_H1 and T_H17 Differentiation in Children with Nontuberculous Mycobacterial Infection. Journal of Infectious Diseases, 220(11), 1843-1847. https://doi.org/10.1093/infdis/jiz371

@article{91ee1683bd5f4c5786ae2319691fed63,

title = "Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children with Nontuberculous Mycobacterial Infection",

abstract = "Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γand interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.",

keywords = "Children, Immune, Mycobacteria, Nontuberculous, NTM, pediatric, T1 and T17 cells",

author = "Claeys, {Tiffany A.} and {Rosas Mejia}, Oscar and Samuel Marshall and Jarzembowski, {Jason A.} and Don Hayes and Hull, {Natalie M.} and Liyanage, {Namal P.M.} and Chun, {Robert H.} and Sulman, {Cecille G.} and Huppler, {Anna R.} and Robinson, {Richard T.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].",

year = "2019",

month = oct,

day = "22",

doi = "10.1093/infdis/jiz371",

language = "English",

volume = "220",

pages = "1843--1847",

number = "11",

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Claeys, TA, Rosas Mejia, O, Marshall, S, Jarzembowski, JA, Hayes, D, Hull, NM, Liyanage, NPM, Chun, RH, Sulman, CG, Huppler, AR & Robinson, RT 2019, 'Attenuation of Helper T Cell Capacity for T_H1 and T_H17 Differentiation in Children with Nontuberculous Mycobacterial Infection', Journal of Infectious Diseases, vol. 220, no. 11, pp. 1843-1847. https://doi.org/10.1093/infdis/jiz371

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T1 - Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children with Nontuberculous Mycobacterial Infection

AU - Claeys, Tiffany A.

AU - Rosas Mejia, Oscar

AU - Marshall, Samuel

AU - Jarzembowski, Jason A.

AU - Hayes, Don

AU - Hull, Natalie M.

AU - Liyanage, Namal P.M.

AU - Chun, Robert H.

AU - Sulman, Cecille G.

AU - Huppler, Anna R.

AU - Robinson, Richard T.

N1 - Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

PY - 2019/10/22

Y1 - 2019/10/22

N2 - Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γand interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.

AB - Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γand interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.

KW - Children

KW - Immune

KW - Mycobacteria

KW - Nontuberculous

KW - NTM

KW - pediatric

KW - T1 and T17 cells

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SN - 0022-1899

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 11

ER -

Attenuation of Helper T Cell Capacity for T_H1 and T_H17 Differentiation in Children with Nontuberculous Mycobacterial Infection

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