Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Nikhat Parveen; Kenneth A. Cornell; James L. Bono; Christen Chamberland; Patricia Rosa; John M. Leong

doi:10.1128/IAI.74.5.3016-3020.2006

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Nikhat Parveen
, Kenneth A. Cornell
, James L. Bono
, Christen Chamberland
, Patricia Rosa
, John M. Leong

Chemistry Department

Rutgers - The State University of New Jersey, Newark
National Institutes of Health
United States Department of Agriculture
University of Massachusetts Medical School

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

Original language	English
Pages (from-to)	3016-3020
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/IAI.74.5.3016-3020.2006
State	Published - May 2006

Access to Document

10.1128/IAI.74.5.3016-3020.2006

Cite this

@article{2886da4a2a5e4882a6fe6343016e3d24,

title = "Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice",

abstract = "Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.",

author = "Nikhat Parveen and Cornell, \{Kenneth A.\} and Bono, \{James L.\} and Christen Chamberland and Patricia Rosa and Leong, \{John M.\}",

year = "2006",

month = may,

doi = "10.1128/IAI.74.5.3016-3020.2006",

language = "English",

volume = "74",

pages = "3016--3020",

number = "5",

}

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. / Parveen, Nikhat; Cornell, Kenneth A.; Bono, James L. et al.
In: Infection and Immunity, Vol. 74, No. 5, 05.2006, p. 3016-3020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

AU - Parveen, Nikhat

AU - Cornell, Kenneth A.

AU - Bono, James L.

AU - Chamberland, Christen

AU - Rosa, Patricia

AU - Leong, John M.

PY - 2006/5

Y1 - 2006/5

N2 - Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

AB - Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

UR - https://www.scopus.com/pages/publications/33646344197

U2 - 10.1128/IAI.74.5.3016-3020.2006

DO - 10.1128/IAI.74.5.3016-3020.2006

M3 - Article

C2 - 16622242

AN - SCOPUS:33646344197

SN - 0019-9567

VL - 74

SP - 3016

EP - 3020

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Abstract

Access to Document

Other files and links

Fingerprint

Cite this