TY - JOUR
T1 - Bioerodible polymers for delivery of macromolecules
AU - Smith, Kelly L.
AU - Schimpf, Martin E.
AU - Thompson, Karen E.
PY - 1990
Y1 - 1990
N2 - The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.
AB - The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.
KW - Biodegradable polymer
KW - Erodible polymer
KW - Poly(ortho-ester)
KW - Poly(α-hydroxy acid)
KW - Polyanhydride
KW - Polyester hydrogel
KW - Polypeptide
UR - http://www.scopus.com/inward/record.url?scp=0025337412&partnerID=8YFLogxK
U2 - 10.1016/0169-409X(90)90026-O
DO - 10.1016/0169-409X(90)90026-O
M3 - Review article
AN - SCOPUS:0025337412
SN - 0169-409X
VL - 4
SP - 343
EP - 357
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 3
ER -