Bioerodible polymers for delivery of macromolecules

Kelly L. Smith; Martin E. Schimpf; Karen E. Thompson

doi:10.1016/0169-409X(90)90026-O

Bioerodible polymers for delivery of macromolecules

Kelly L. Smith, Martin E. Schimpf, Karen E. Thompson

Chemistry Department

Bend Research Incorporated

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.

Original language	English
Pages (from-to)	343-357
Number of pages	15
Journal	Advanced Drug Delivery Reviews
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0169-409X(90)90026-O
State	Published - 1990

Keywords

Biodegradable polymer
Erodible polymer
Poly(ortho-ester)
Poly(α-hydroxy acid)
Polyanhydride
Polyester hydrogel
Polypeptide

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10.1016/0169-409X(90)90026-O

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title = "Bioerodible polymers for delivery of macromolecules",

abstract = "The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.",

keywords = "Biodegradable polymer, Erodible polymer, Poly(ortho-ester), Poly(α-hydroxy acid), Polyanhydride, Polyester hydrogel, Polypeptide",

author = "Smith, \{Kelly L.\} and Schimpf, \{Martin E.\} and Thompson, \{Karen E.\}",

year = "1990",

doi = "10.1016/0169-409X(90)90026-O",

language = "English",

volume = "4",

pages = "343--357",

number = "3",

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TY - JOUR

T1 - Bioerodible polymers for delivery of macromolecules

AU - Smith, Kelly L.

AU - Schimpf, Martin E.

AU - Thompson, Karen E.

PY - 1990

Y1 - 1990

N2 - The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.

AB - The delivery of peptides, proteins and other macromolecules to humans and animals has become increasingly important to the medical community. However, these drugs are difficult to administer because of their size, solubility and lability. Erodible polymers offer certain advantages over other methods of administering these drugs. The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides. The characteristics and status of each of these types of erodible polymers are reviewed below.

KW - Biodegradable polymer

KW - Erodible polymer

KW - Poly(ortho-ester)

KW - Poly(α-hydroxy acid)

KW - Polyanhydride

KW - Polyester hydrogel

KW - Polypeptide

UR - https://www.scopus.com/pages/publications/0025337412

U2 - 10.1016/0169-409X(90)90026-O

DO - 10.1016/0169-409X(90)90026-O

M3 - Review article

AN - SCOPUS:0025337412

SN - 0169-409X

VL - 4

SP - 343

EP - 357

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 3

ER -

Bioerodible polymers for delivery of macromolecules

Abstract

Keywords

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