Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases

Patrick D. Fischer; Abu Sayeed Chowdhury; Thomas Bartholow; Shibani Basu; Eric Baggs; Huel S. Cox; Srđan Matošin; Michael D. Burkart; Lisa Warner; Rajesh Nagarajan; Haribabu Arthanari

doi:10.1039/d2cc03551k

Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases

Patrick D. Fischer
, Abu Sayeed Chowdhury
, Thomas Bartholow
, Shibani Basu
, Eric Baggs
, Huel S. Cox
, Srđan Matošin
, Michael D. Burkart
, Lisa Warner
, Rajesh Nagarajan
, Haribabu Arthanari

Chemistry Department

Harvard University
Dana-Farber Cancer Institute
Saarland University
Boise State University
University of California at San Diego

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein–enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

Original language	American English
Pages (from-to)	1014-1017
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	8
DOIs	https://doi.org/10.1039/d2cc03551k
State	Published - 25 Jan 2023

EGS Disciplines

Chemistry

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10.1039/d2cc03551k

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title = "Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases",

abstract = " Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein–enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.",

author = "Fischer, \{Patrick D.\} and Chowdhury, \{Abu Sayeed\} and Thomas Bartholow and Shibani Basu and Eric Baggs and Cox, \{Huel S.\} and Sr{\d}an Mato{\v s}in and Burkart, \{Michael D.\} and Lisa Warner and Rajesh Nagarajan and Haribabu Arthanari",

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year = "2023",

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day = "25",

doi = "10.1039/d2cc03551k",

language = "American English",

volume = "59",

pages = "1014--1017",

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TY - JOUR

T1 - Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases

AU - Fischer, Patrick D.

AU - Chowdhury, Abu Sayeed

AU - Bartholow, Thomas

AU - Basu, Shibani

AU - Baggs, Eric

AU - Cox, Huel S.

AU - Matošin, Srđan

AU - Burkart, Michael D.

AU - Warner, Lisa

AU - Nagarajan, Rajesh

AU - Arthanari, Haribabu

PY - 2023/1/25

Y1 - 2023/1/25

N2 - Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein–enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

AB - Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein–enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

UR - https://www.scopus.com/pages/publications/85146804409

UR - https://scholarworks.boisestate.edu/chem_facpubs/164

U2 - 10.1039/d2cc03551k

DO - 10.1039/d2cc03551k

M3 - Article

C2 - 36645064

SN - 1359-7345

VL - 59

SP - 1014

EP - 1017

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Carrier Protein Mediated Cargo Sensing in Quorum Signal Synthases

Abstract

EGS Disciplines

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