Abstract
Optimal cellular responses rely on effective sensing and intracellular transduction of environmental information. This information is either coded in the extracellular matrix as growth factors or activated by mechanosensitive signaling cascades through dynamic environmental force gradients. Cells utilize a variety of subcellular structures, proteins, and adaptation strategies to decode and use this information. This chapter will focus on load-bearing cellular structures that convert physical information into intracellular signals and structures that dynamically adapt to the force state to control subsequent signaling. This chapter will discuss relevant structures and signaling events that initiate from the plasma membrane, the cytoskeleton, and the nucleus.
Original language | English |
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Title of host publication | Mechanobiology |
Subtitle of host publication | From Molecular Sensing to Disease |
Pages | 79-98 |
Number of pages | 20 |
ISBN (Electronic) | 9780128179314 |
DOIs | |
State | Published - 1 Jan 2019 |
Keywords
- Cytoskeleton
- Focal adhesions
- LINC
- Mechanotransduction
- Nucleus
- Stem cells