Cells as functional load sensors and drivers of adaptation

Matthew Goelzer, William R. Thompson, Gunes Uzer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Optimal cellular responses rely on effective sensing and intracellular transduction of environmental information. This information is either coded in the extracellular matrix as growth factors or activated by mechanosensitive signaling cascades through dynamic environmental force gradients. Cells utilize a variety of subcellular structures, proteins, and adaptation strategies to decode and use this information. This chapter will focus on load-bearing cellular structures that convert physical information into intracellular signals and structures that dynamically adapt to the force state to control subsequent signaling. This chapter will discuss relevant structures and signaling events that initiate from the plasma membrane, the cytoskeleton, and the nucleus.

Original languageEnglish
Title of host publicationMechanobiology
Subtitle of host publicationFrom Molecular Sensing to Disease
Pages79-98
Number of pages20
ISBN (Electronic)9780128179314
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Cytoskeleton
  • Focal adhesions
  • LINC
  • Mechanotransduction
  • Nucleus
  • Stem cells

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