Collagen a1 (XI) structure prediction by Alphafold 2

Abu Sayeed Chowdhury, Julia Thom Oxford

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Collagen αt (XI) is a minor fibrillar collagen involved in the critical regulation of collagen fibrils such as nucleation, assembly, and regulation of fibril diameter. The amino propeptide domain of the collagen αt (XI) is retained on the surface of the collagen fibril for an extended period of time and may playa crucial role in the interaction with extracellular matrix glycosaminoglycans and other proteins during the process of fibrillogenesis. Understanding the mechanism of action of this protein will ultimately help us understand the organization and assembly of the extracellular matrix that underlies the structural integrity of connective tissues.

Original languageEnglish
Title of host publicationProceedings - 2022 International Conference on Computational Science and Computational Intelligence, CSCI 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages572-577
Number of pages6
ISBN (Electronic)9798350320282
DOIs
StatePublished - 2022
Event2022 International Conference on Computational Science and Computational Intelligence, CSCI 2022 - Las Vegas, United States
Duration: 14 Dec 202216 Dec 2022

Publication series

NameProceedings - 2022 International Conference on Computational Science and Computational Intelligence, CSCI 2022

Conference

Conference2022 International Conference on Computational Science and Computational Intelligence, CSCI 2022
Country/TerritoryUnited States
CityLas Vegas
Period14/12/2216/12/22

Keywords

  • Alphafold 2
  • amino propeptide domain
  • collagen αl (XI)
  • fibrillogenesis
  • glycosaminoglycans

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