Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

Hemakesh Mohapatra; Kyle M. Schmid; Scott T. Phillips

doi:10.1039/c2cc17566e

Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

Hemakesh Mohapatra, Kyle M. Schmid, Scott T. Phillips

Micron School of Materials Science and Engineering

Pennsylvania State University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

Original language	English
Pages (from-to)	3018-3020
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	24
DOIs	https://doi.org/10.1039/c2cc17566e
State	Published - 22 Feb 2012

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title = "Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction",

abstract = "This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.",

author = "Hemakesh Mohapatra and Schmid, \{Kyle M.\} and Phillips, \{Scott T.\}",

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AU - Mohapatra, Hemakesh

AU - Schmid, Kyle M.

AU - Phillips, Scott T.

PY - 2012/2/22

Y1 - 2012/2/22

N2 - This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

AB - This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

UR - https://www.scopus.com/pages/publications/84857590761

U2 - 10.1039/c2cc17566e

DO - 10.1039/c2cc17566e

M3 - Article

AN - SCOPUS:84857590761

SN - 1359-7345

VL - 48

SP - 3018

EP - 3020

JO - Chemical Communications

JF - Chemical Communications

IS - 24

ER -

Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

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