Development and characterization of a low intensity vibrational system for microgravity studies

Omor M. Khan; Will Gasperini; Chess Necessary; Zach Jacobs; Sam Perry; Jason Rexroat; Kendall Nelson; Paul Gamble; Twyman Clements; Maximilien DeLeon; Sean Howard; Anamaria Zavala; Mary Farach-Carson; Elizabeth Blaber; Danielle Wu; Aykut Satici; Gunes Uzer

doi:10.1038/s41526-024-00444-x

Development and characterization of a low intensity vibrational system for microgravity studies

Omor M. Khan, Will Gasperini, Chess Necessary, Zach Jacobs, Sam Perry, Jason Rexroat, Kendall Nelson, Paul Gamble, Twyman Clements, Maximilien DeLeon, Sean Howard, Anamaria Zavala, Mary Farach-Carson, Elizabeth Blaber, Danielle Wu, Aykut Satici, Gunes Uzer

Mechanical and Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

Abstract

Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.

Original language	English
Article number	107
Journal	npj Microgravity
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41526-024-00444-x
State	Published - Dec 2024

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Khan, O. M., Gasperini, W., Necessary, C., Jacobs, Z., Perry, S., Rexroat, J., Nelson, K., Gamble, P., Clements, T., DeLeon, M., Howard, S., Zavala, A., Farach-Carson, M., Blaber, E., Wu, D., Satici, A., & Uzer, G. (2024). Development and characterization of a low intensity vibrational system for microgravity studies. npj Microgravity, 10(1), Article 107. https://doi.org/10.1038/s41526-024-00444-x

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abstract = "Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor{\textquoteright}s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.",

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Khan, OM, Gasperini, W, Necessary, C, Jacobs, Z, Perry, S, Rexroat, J, Nelson, K, Gamble, P, Clements, T, DeLeon, M, Howard, S, Zavala, A, Farach-Carson, M, Blaber, E, Wu, D, Satici, A & Uzer, G 2024, 'Development and characterization of a low intensity vibrational system for microgravity studies', npj Microgravity, vol. 10, no. 1, 107. https://doi.org/10.1038/s41526-024-00444-x

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AU - Khan, Omor M.

AU - Gasperini, Will

AU - Necessary, Chess

AU - Jacobs, Zach

AU - Perry, Sam

AU - Rexroat, Jason

AU - Nelson, Kendall

AU - Gamble, Paul

AU - Clements, Twyman

AU - DeLeon, Maximilien

AU - Howard, Sean

AU - Zavala, Anamaria

AU - Farach-Carson, Mary

AU - Blaber, Elizabeth

AU - Wu, Danielle

AU - Satici, Aykut

AU - Uzer, Gunes

PY - 2024/12

Y1 - 2024/12

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AB - Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.

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Development and characterization of a low intensity vibrational system for microgravity studies

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