Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

Kevin Feris; Caitlin Otto; Juliette Tinker; Denise G. Wingett; Alex Punnoose; Aaron Thurber; Madhu Kongara; Maryam Sabetian; Bonnie Quinn; Charles Hanna; David Pink

doi:10.1021/la903491z

Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

Kevin Feris, Caitlin Otto, Juliette Tinker, Denise G. Wingett, Alex Punnoose, Aaron Thurber, Madhu Kongara, Maryam Sabetian, Bonnie Quinn, Charles Hanna, David Pink

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.

Original language	American English
Pages (from-to)	4429-36
Number of pages	8
Journal	Langmuir
Volume	26
Issue number	6
DOIs	https://doi.org/10.1021/la903491z
State	Published - 16 Mar 2010

Keywords

Hydrogen Bonding
Models, Theoretical
Nanoparticles
Pseudomonas aeruginosa/drug effects
Static Electricity

EGS Disciplines

Biology

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http://dx.doi.org/10.1021/la903491z

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title = "Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1",

abstract = "Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.",

keywords = "Hydrogen Bonding, Models, Theoretical, Nanoparticles, Pseudomonas aeruginosa/drug effects, Static Electricity",

author = "Kevin Feris and Caitlin Otto and Juliette Tinker and Wingett, {Denise G.} and Alex Punnoose and Aaron Thurber and Madhu Kongara and Maryam Sabetian and Bonnie Quinn and Charles Hanna and David Pink",

year = "2010",

month = mar,

day = "16",

doi = "10.1021/la903491z",

language = "American English",

volume = "26",

pages = "4429--36",

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TY - JOUR

T1 - Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

AU - Feris, Kevin

AU - Otto, Caitlin

AU - Tinker, Juliette

AU - Wingett, Denise G.

AU - Punnoose, Alex

AU - Thurber, Aaron

AU - Kongara, Madhu

AU - Sabetian, Maryam

AU - Quinn, Bonnie

AU - Hanna, Charles

AU - Pink, David

PY - 2010/3/16

Y1 - 2010/3/16

N2 - Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.

AB - Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.

KW - Hydrogen Bonding

KW - Models, Theoretical

KW - Nanoparticles

KW - Pseudomonas aeruginosa/drug effects

KW - Static Electricity

UR - https://scholarworks.boisestate.edu/bio_facpubs/100

UR - http://dx.doi.org/10.1021/la903491z

U2 - 10.1021/la903491z

DO - 10.1021/la903491z

M3 - Article

C2 - 20000362

SN - 0743-7463

VL - 26

SP - 4429

EP - 4436

JO - Langmuir

JF - Langmuir

IS - 6

ER -

Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

Abstract

Keywords

EGS Disciplines

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