Emerging Genetic Basis of Osteochondritis Dissecans

J. Tyler Bates, John C. Jacobs, Kevin G. Shea, Julia Thom Oxford

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Osteochondritis dissecans (OCD) is a focal idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis (OA). 1 This condition is commonly found in horses, pigs, dogs, and humans 2 . König 3 first used the term OCD to describe a condition that causes the formation of loose bodies in the joints of young individuals without arthritis or trauma. Although more than 100 years have passed since König 3 described OCD, little knowledge exists of the specific etiology and pathogenesis of this disease. Many etiologic theories have been proposed for the onset and progression of OCD, including trauma, diet, rapid growth, anatomic characteristics, lack of blood supply, necrosis of subchondral bone, and heredity (recently reviewed in Refs. 4-8 ). Recent experiments have provided additional information regarding the underlying genetic traits that may predispose an individual to OCD.

Original languageAmerican English
JournalBiomolecular Research Institute Publications and Presentations
DOIs
StatePublished - 1 Apr 2014

Keywords

  • Osteoarthritis
  • Osteochondritis dissecans
  • Osteochondrosis
  • equine
  • genome-wide association study
  • human
  • single nucleotide polymorphism
  • swine

EGS Disciplines

  • Molecular Biology

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