TY - JOUR
T1 - Emerging Genetic Basis of Osteochondritis Dissecans
AU - Bates, J. Tyler
AU - Jacobs, John C.
AU - Shea, Kevin G.
AU - Oxford, Julia Thom
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Osteochondritis dissecans (OCD) is a focal idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis (OA). 1 This condition is commonly found in horses, pigs, dogs, and humans 2 . König 3 first used the term OCD to describe a condition that causes the formation of loose bodies in the joints of young individuals without arthritis or trauma. Although more than 100 years have passed since König 3 described OCD, little knowledge exists of the specific etiology and pathogenesis of this disease. Many etiologic theories have been proposed for the onset and progression of OCD, including trauma, diet, rapid growth, anatomic characteristics, lack of blood supply, necrosis of subchondral bone, and heredity (recently reviewed in Refs. 4-8 ). Recent experiments have provided additional information regarding the underlying genetic traits that may predispose an individual to OCD.
AB - Osteochondritis dissecans (OCD) is a focal idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis (OA). 1 This condition is commonly found in horses, pigs, dogs, and humans 2 . König 3 first used the term OCD to describe a condition that causes the formation of loose bodies in the joints of young individuals without arthritis or trauma. Although more than 100 years have passed since König 3 described OCD, little knowledge exists of the specific etiology and pathogenesis of this disease. Many etiologic theories have been proposed for the onset and progression of OCD, including trauma, diet, rapid growth, anatomic characteristics, lack of blood supply, necrosis of subchondral bone, and heredity (recently reviewed in Refs. 4-8 ). Recent experiments have provided additional information regarding the underlying genetic traits that may predispose an individual to OCD.
KW - Osteoarthritis
KW - Osteochondritis dissecans
KW - Osteochondrosis
KW - equine
KW - genome-wide association study
KW - human
KW - single nucleotide polymorphism
KW - swine
UR - https://scholarworks.boisestate.edu/brc_facpubs/15
UR - http://dx.doi.org/10.1016/j.csm.2013.11.004
U2 - 10.1016/j.csm.2013.11.004
DO - 10.1016/j.csm.2013.11.004
M3 - Article
C2 - 24698039
JO - Biomolecular Research Institute Publications and Presentations
JF - Biomolecular Research Institute Publications and Presentations
ER -