Facile synthesis of @-tide β-strand peptidomimetics: Improved assembly in solution and on solid phase

Scott T. Phillips; Giovanni Piersanti; Matthias Rüth; Niko Gubernator; Bettina Van Lengerich; Paul A. Bartlett

doi:10.1021/ol048262j

Facile synthesis of @-tide β-strand peptidomimetics: Improved assembly in solution and on solid phase

Scott T. Phillips, Giovanni Piersanti, Matthias Rüth, Niko Gubernator, Bettina Van Lengerich, Paul A. Bartlett

Micron School of Materials Science and Engineering

University of California at Berkeley

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

(Chemical equation presented) The synthesis of @-tide β-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units.

Original language	English
Pages (from-to)	4483-4485
Number of pages	3
Journal	Organic Letters
Volume	6
Issue number	24
DOIs	https://doi.org/10.1021/ol048262j
State	Published - 25 Nov 2004

Keywords

Combinatorial Chemistry Techniques
Molecular Mimicry
Oligopeptides/chemical synthesis

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10.1021/ol048262j

Cite this

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title = "Facile synthesis of @-tide β-strand peptidomimetics: Improved assembly in solution and on solid phase",

abstract = "(Chemical equation presented) The synthesis of @-tide β-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units.",

keywords = "Combinatorial Chemistry Techniques, Molecular Mimicry, Oligopeptides/chemical synthesis",

author = "Phillips, \{Scott T.\} and Giovanni Piersanti and Matthias R{\"u}th and Niko Gubernator and \{Van Lengerich\}, Bettina and Bartlett, \{Paul A.\}",

year = "2004",

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doi = "10.1021/ol048262j",

language = "English",

volume = "6",

pages = "4483--4485",

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T1 - Facile synthesis of @-tide β-strand peptidomimetics

T2 - Improved assembly in solution and on solid phase

AU - Phillips, Scott T.

AU - Piersanti, Giovanni

AU - Rüth, Matthias

AU - Gubernator, Niko

AU - Van Lengerich, Bettina

AU - Bartlett, Paul A.

PY - 2004/11/25

Y1 - 2004/11/25

N2 - (Chemical equation presented) The synthesis of @-tide β-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units.

AB - (Chemical equation presented) The synthesis of @-tide β-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units.

KW - Combinatorial Chemistry Techniques

KW - Molecular Mimicry

KW - Oligopeptides/chemical synthesis

UR - https://www.scopus.com/pages/publications/10044264453

U2 - 10.1021/ol048262j

DO - 10.1021/ol048262j

M3 - Article

C2 - 15548056

AN - SCOPUS:10044264453

SN - 1523-7060

VL - 6

SP - 4483

EP - 4485

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Facile synthesis of @-tide β-strand peptidomimetics: Improved assembly in solution and on solid phase

Abstract

Keywords

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