TY - JOUR
T1 - Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model (review)
AU - Yoshidome, Katsuhide
AU - Shibata, Masa Aki
AU - Maroulakou, Ioanna G.
AU - Liu, Min Ling
AU - Jorcyk, Cheryl L.
AU - Gold, Lyng
AU - Welch, Valerie N.
AU - Green, Jeffrey E.
PY - 1998/2
Y1 - 1998/2
N2 - We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs.
AB - We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs.
KW - C3(1)
KW - Mammary carcinogenesis
KW - Prostate carcinogenesis
KW - Prostatic steroid binding protein
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=0031907624&partnerID=8YFLogxK
M3 - Article
C2 - 9458374
AN - SCOPUS:0031907624
SN - 1019-6439
VL - 12
SP - 449
EP - 453
JO - International Journal of Oncology
JF - International Journal of Oncology
IS - 2
ER -