Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model (review)

Katsuhide Yoshidome, Masa Aki Shibata, Ioanna G. Maroulakou, Min Ling Liu, Cheryl L. Jorcyk, Lyng Gold, Valerie N. Welch, Jeffrey E. Green

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalInternational Journal of Oncology
Volume12
Issue number2
StatePublished - Feb 1998

Keywords

  • C3(1)
  • Mammary carcinogenesis
  • Prostate carcinogenesis
  • Prostatic steroid binding protein
  • Transgenic mice

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