Glucocorticoid-mediated inhibition of RANTES expression in human T lymphocytes

Denise Wingett, Kristin Forcier, Christopher P. Nielson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The chemokine RANTES has been implicated in the pathogenesis of allergic inflammatory diseases including asthma and rhinitis which are frequently treated with glucocorticoids. We observed that dexamethasone dramatically inhibited RANTES mRNA expression dose dependently in anti-CD3 activated Hut-78 T cells and human PBMCs. Inhibition of RANTES expression did not appear to be secondary to IL-2 inhibition and required binding to the intracellular glucocorticoid receptor. The down-regulation of RANTES expression by glucocorticoids in T cells may directly contribute to the efficacy of these agents in suppressing cellular infiltration and to their anti-inflammatory properties.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalFEBS Letters
Volume398
Issue number2-3
DOIs
StatePublished - 2 Dec 1996

Keywords

  • Dexamethasone
  • Glucocorticoid
  • RANTES
  • T cell

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