Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis

Kristina Hoffman, William J. Doyle, Sean M. Schumacher, Javier Ochoa-Repáraz

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations

Abstract

Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the “Western diet” as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease.

Original languageEnglish
Article number1146748
JournalFrontiers in Nutrition
Volume10
DOIs
StatePublished - 2023

Keywords

  • diet
  • dietary factors
  • dietary interventions
  • EAE
  • gut dysbiosis
  • gut microbiome
  • multiple sclerosis

Fingerprint

Dive into the research topics of 'Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis'. Together they form a unique fingerprint.

Cite this