TY - JOUR
T1 - Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
AU - Hoffman, Kristina
AU - Doyle, William J.
AU - Schumacher, Sean M.
AU - Ochoa-Repáraz, Javier
N1 - Publisher Copyright:
Copyright © 2023 Hoffman, Doyle, Schumacher and Ochoa-Repáraz.
PY - 2023
Y1 - 2023
N2 - Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the “Western diet” as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease.
AB - Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the “Western diet” as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease.
KW - diet
KW - dietary factors
KW - dietary interventions
KW - EAE
KW - gut dysbiosis
KW - gut microbiome
KW - multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85152705909&partnerID=8YFLogxK
U2 - 10.3389/fnut.2023.1146748
DO - 10.3389/fnut.2023.1146748
M3 - Short survey
AN - SCOPUS:85152705909
VL - 10
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 1146748
ER -