TY - JOUR
T1 - Herbs and Spices
T2 - Modulation of Gut Microbiota for Healthy Aging
AU - Pradhan, Samjhana
AU - Blanton, Cynthia
AU - Ochoa-Reparaz, Javier
AU - Bhattarai, Nirajan
AU - Sharma, Kavita
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/6
Y1 - 2024/6
N2 - The gut microbiota interacts with the host’s immune function, and evidence supports a relationship between the gut microbiota and age-related disease. Consumption of herbs and spices, which contain bioactive compounds such as polyphenols, is associated with gut microbiota characteristics that may act to prevent or manage age-related declines in health. This review evaluates the evidence describing the effect of herb/spice intake on the gut microbiota and health during aging. Commonly consumed herbs/spices, their impact on prominent gut bacteria phyla (Bacteriodetes, Firmicutes), and diseases of aging are highlighted. Studies in humans and animals are reviewed. Mechanisms of action are discussed, and future directions for research are proposed. Dietary enrichment with herbs and spices is a potential novel intervention for mitigating declines in physiological function with age.
AB - The gut microbiota interacts with the host’s immune function, and evidence supports a relationship between the gut microbiota and age-related disease. Consumption of herbs and spices, which contain bioactive compounds such as polyphenols, is associated with gut microbiota characteristics that may act to prevent or manage age-related declines in health. This review evaluates the evidence describing the effect of herb/spice intake on the gut microbiota and health during aging. Commonly consumed herbs/spices, their impact on prominent gut bacteria phyla (Bacteriodetes, Firmicutes), and diseases of aging are highlighted. Studies in humans and animals are reviewed. Mechanisms of action are discussed, and future directions for research are proposed. Dietary enrichment with herbs and spices is a potential novel intervention for mitigating declines in physiological function with age.
KW - anti-inflammatory
KW - antioxidant
KW - mammalian target of rapamycin (mTOR)
KW - polyphenols
KW - prebiotics
UR - http://www.scopus.com/inward/record.url?scp=85196889339&partnerID=8YFLogxK
U2 - 10.3390/gastroent15020032
DO - 10.3390/gastroent15020032
M3 - Review article
AN - SCOPUS:85196889339
VL - 15
SP - 447
EP - 458
JO - Gastroenterology Insights
JF - Gastroenterology Insights
IS - 2
ER -