TY - JOUR
T1 - High Cholesterol/Low Cholesterol
T2 - Effects in Biological Membranes: A Review
AU - Subczynski, Witold K.
AU - Pasenkiewicz-Gierula, Marta
AU - Widomska, Justyna
AU - Mainali, Laxman
AU - Raguz, Marija
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms. In this review, we discuss the major membrane properties induced by cholesterol, and their relationship to certain membrane functions.
AB - Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms. In this review, we discuss the major membrane properties induced by cholesterol, and their relationship to certain membrane functions.
KW - Cholesterol
KW - EPR
KW - Lipid spin label
KW - Membrane domains
KW - Oximetry
UR - https://www.scopus.com/pages/publications/85017521790
U2 - 10.1007/s12013-017-0792-7
DO - 10.1007/s12013-017-0792-7
M3 - Article
C2 - 28417231
AN - SCOPUS:85017521790
SN - 1085-9195
VL - 75
SP - 369
EP - 385
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
IS - 3-4
ER -