TY - JOUR
T1 - Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson’s Disease Brain
AU - Rohn, Troy T.
AU - Catlin, Lindsey W.
PY - 2011/5/31
Y1 - 2011/5/31
N2 - Although much is known regarding the molecular mechanisms leading to neuronal cell loss in Parkinson’s disease (PD), the initiating event has not been identified. Prevailing theories including a chemical insult or infectious agent have been postulated as possible triggers, leading to neuroinflammation. We present immunohistochemical data indicating the presence of influenza A virus within the substantia nigra pars compacta (SNpc) from postmortem PD brain sections. Influenza A virus labeling was identified within neuromelanin granules as well as on tissue macrophages in the SNpc. Further supporting a role for neuroinflammation in PD was the identification of T-lymphocytes that colocalized with an antibody to caspase-cleaved Beclin-1 within the SNpc. The presence of influenza A virus together with macrophages and Tlymphocytes may contribute to the neuroinflammation associated with this disease.
AB - Although much is known regarding the molecular mechanisms leading to neuronal cell loss in Parkinson’s disease (PD), the initiating event has not been identified. Prevailing theories including a chemical insult or infectious agent have been postulated as possible triggers, leading to neuroinflammation. We present immunohistochemical data indicating the presence of influenza A virus within the substantia nigra pars compacta (SNpc) from postmortem PD brain sections. Influenza A virus labeling was identified within neuromelanin granules as well as on tissue macrophages in the SNpc. Further supporting a role for neuroinflammation in PD was the identification of T-lymphocytes that colocalized with an antibody to caspase-cleaved Beclin-1 within the SNpc. The presence of influenza A virus together with macrophages and Tlymphocytes may contribute to the neuroinflammation associated with this disease.
UR - https://scholarworks.boisestate.edu/bio_facpubs/101
UR - http://www.scopus.com/inward/record.url?scp=79957792153&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0020495
DO - 10.1371/journal.pone.0020495
M3 - Article
C2 - 21655265
VL - 6
JO - History Faculty Publications and Presentations
JF - History Faculty Publications and Presentations
IS - 5
M1 - e20495
ER -
