In-vitro validated methods for encoding digital data in deoxyribonucleic acid (DNA)

Golam Md Mortuza; Jorge Guerrero; Shoshanna Llewellyn; Michael D. Tobiason; George D. Dickinson; William L. Hughes; Reza Zadegan; Tim Andersen

doi:10.1186/s12859-023-05264-6

In-vitro validated methods for encoding digital data in deoxyribonucleic acid (DNA)

Golam Md Mortuza, Jorge Guerrero, Shoshanna Llewellyn, Michael D. Tobiason, George D. Dickinson, William L. Hughes, Reza Zadegan, Tim Andersen

Computer Science Department

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.

Original language	English
Article number	160
Journal	BMC Bioinformatics
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s12859-023-05264-6
State	Published - Dec 2023

Keywords

DNA
Data storage
Error correction
Information encoding
Nucleic acid memory

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10.1186/s12859-023-05264-6

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title = "In-vitro validated methods for encoding digital data in deoxyribonucleic acid (DNA)",

abstract = "Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.",

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AU - Mortuza, Golam Md

AU - Guerrero, Jorge

AU - Llewellyn, Shoshanna

AU - Tobiason, Michael D.

AU - Dickinson, George D.

AU - Hughes, William L.

AU - Zadegan, Reza

AU - Andersen, Tim

PY - 2023/12

Y1 - 2023/12

N2 - Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.

AB - Deoxyribonucleic acid (DNA) is emerging as an alternative archival memory technology. Recent advancements in DNA synthesis and sequencing have both increased the capacity and decreased the cost of storing information in de novo synthesized DNA pools. In this survey, we review methods for translating digital data to and/or from DNA molecules. An emphasis is placed on methods which have been validated by storing and retrieving real-world data via in-vitro experiments.

KW - DNA

KW - Data storage

KW - Error correction

KW - Information encoding

KW - Nucleic acid memory

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JO - BMC Bioinformatics

JF - BMC Bioinformatics

IS - 1

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ER -

In-vitro validated methods for encoding digital data in deoxyribonucleic acid (DNA)

Abstract

Keywords

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