Incorporation of bioactive materials into integrated systems

Bruce C. Bunker, Dale L. Huber, Ronald P. Manginell, Byung Il Kim, Andrew K. Boal, George D. Bachand, Susan B. Rivera, Joseph M. Bauer, Carolyn Matzke

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations

Abstract

Sandia is exploring two classes of integrated systems involving bioactive materials: 1) microfluidic systems that can be used to manipulate biomolecules for applications ranging from counter-terrorism to drug delivery systems, and 2) fluidic systems in which active biomolecules such as motor proteins provide specific functions such as active transport. An example of the first class involves the development of a reversible protein trap based on the integration of the thermally-switchable polymer poly(N-isopropylacrylamide)(PNIPAM) into a micro-hotplate device. To exemplify the second class, we describe the technical challenges associated with integrating microtubules and motor proteins into microfluidic systems for: 1) the active transport of nanoparticle cargo, or 2) templated growth of high-aspect ratio nanowires. These examples illustrate the functions of bioactive materials, synthesis and fabrication issues, mechanisms for switching surface chemistry and active transport, and new techniques such as the interfacial force microscope (IFM) that can be used to characterize bioactive surfaces.

Original languageEnglish
Pages (from-to)28-36
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5220
DOIs
StatePublished - 2003
EventNanofabrication Technologies - San Diego, CA, United States
Duration: 3 Aug 20034 Aug 2003

Keywords

  • Bio-active monolayers
  • Microfluidic systems
  • Microtubules
  • Motor proteins
  • Protein adsorption

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