Label-free imaging of metal-carbonyl complexes in live cells by raman microspectroscopy

Konrad Meister, Johanna Niesel, Ulrich Schatzschneider, Nils Metzler-Nolte, Diedrich A. Schmidt, Martina Havenith

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

(Figure Presented) A new kid in town: 3D Raman intensity images of a HT29 colon cancer cell incubated with an aqueous solution of the CO-releasing metal-carbonyl complex 1 show that the compound penetrates the cellular membrane and is localized mainly in the nuclear membrane and the nuclelus. The C≡O vibration of l serves as an intrinsic spectroscopic label.

Original languageEnglish
Pages (from-to)3310-3312
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number19
DOIs
StatePublished - 26 Apr 2010

Keywords

  • Bioorganometallic chemistry
  • Infrared microscopy
  • Medicinal chemistry
  • Metal-carbonyl complexes
  • Molecular imaging

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