TY - JOUR
T1 - Label-free imaging of metal-carbonyl complexes in live cells by raman microspectroscopy
AU - Meister, Konrad
AU - Niesel, Johanna
AU - Schatzschneider, Ulrich
AU - Metzler-Nolte, Nils
AU - Schmidt, Diedrich A.
AU - Havenith, Martina
PY - 2010/4/26
Y1 - 2010/4/26
N2 - (Figure Presented) A new kid in town: 3D Raman intensity images of a HT29 colon cancer cell incubated with an aqueous solution of the CO-releasing metal-carbonyl complex 1 show that the compound penetrates the cellular membrane and is localized mainly in the nuclear membrane and the nuclelus. The C≡O vibration of l serves as an intrinsic spectroscopic label.
AB - (Figure Presented) A new kid in town: 3D Raman intensity images of a HT29 colon cancer cell incubated with an aqueous solution of the CO-releasing metal-carbonyl complex 1 show that the compound penetrates the cellular membrane and is localized mainly in the nuclear membrane and the nuclelus. The C≡O vibration of l serves as an intrinsic spectroscopic label.
KW - Bioorganometallic chemistry
KW - Infrared microscopy
KW - Medicinal chemistry
KW - Metal-carbonyl complexes
KW - Molecular imaging
UR - http://www.scopus.com/inward/record.url?scp=77951669928&partnerID=8YFLogxK
U2 - 10.1002/anie.201000097
DO - 10.1002/anie.201000097
M3 - Article
C2 - 20349485
AN - SCOPUS:77951669928
SN - 1433-7851
VL - 49
SP - 3310
EP - 3312
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 19
ER -