Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

Samuel Barker; Eric Rhoads; Paul Lindquist; Martin Vreugdenhil; Peter Müllner

doi:10.1115/1.4034576

Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

Samuel Barker, Eric Rhoads, Paul Lindquist, Martin Vreugdenhil, Peter Müllner

Micron School of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.

Original language	American English
Article number	041009
Number of pages	6
Journal	Journal of Medical Devices
Volume	10
Issue number	4
DOIs	https://doi.org/10.1115/1.4034576
State	Published - Dec 2016

Keywords

design
engines
flow (dynamics)
fluids
micropumps
pumps
shapes

EGS Disciplines

Materials Science and Engineering

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10.1115/1.4034576

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title = "Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats",

abstract = "Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.",

keywords = "design, engines, flow (dynamics), fluids, micropumps, pumps, shapes",

author = "Samuel Barker and Eric Rhoads and Paul Lindquist and Martin Vreugdenhil and Peter M{\"u}llner",

note = "Publisher Copyright: {\textcopyright} 2016 by ASME.",

year = "2016",

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doi = "10.1115/1.4034576",

language = "American English",

volume = "10",

number = "4",

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TY - JOUR

T1 - Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

AU - Barker, Samuel

AU - Rhoads, Eric

AU - Lindquist, Paul

AU - Vreugdenhil, Martin

AU - Müllner, Peter

PY - 2016/12

Y1 - 2016/12

N2 - Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.

AB - Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.

KW - design

KW - engines

KW - flow (dynamics)

KW - fluids

KW - micropumps

KW - pumps

KW - shapes

UR - https://www.scopus.com/pages/publications/84987858848

UR - https://scholarworks.boisestate.edu/mse_facpubs/279

U2 - 10.1115/1.4034576

DO - 10.1115/1.4034576

M3 - Article

VL - 10

JO - Journal of Medical Devices

JF - Journal of Medical Devices

IS - 4

M1 - 041009

ER -

Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

Abstract

Keywords

EGS Disciplines

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