MTN Deficiency Attenuates Bacterial Biofilms and Adherence to the Extracellular Matrix

Ally Isnor; Jason Stonick; Kenneth Cornell

MTN Deficiency Attenuates Bacterial Biofilms and Adherence to the Extracellular Matrix

Ally Isnor, Jason Stonick, Kenneth Cornell

Chemistry Department

Boise State University

Research output: Contribution to conference › Poster

Abstract

The enzyme methylthioadenosine nucleosidase (MTN) and its downstream pathways play a role in promoting many potent virulence phenotypes among gram negative bacterial pathogens. These phenotypes include both the formation of biofilms and adherence to mammalian extracellular matrix proteins (ECM) during infection that promote pathogenicity and infection. The role of MTN in these processes was examined by studying the effect of MTN inhibitors and genetic knock-out strains to reduce biofilms and ECM adherence in two model pathogens of Escherichia coli O157:H7 and Klebsiella pneumonia . The results of our studies indicate that deficiency of MTN activity decreases biofilms and ECM adherence, and supports virulence attenuation as a mechanism of action for MTN inhibitors.

Original language	American English
State	Published - 1 Jul 2015
Event	Idaho Conference on Undergraduate Research 2015 - Boise State University, Boise, United States Duration: 1 Jul 2015 → … https://scholarworks.boisestate.edu/icur/2015/

Conference

Conference	Idaho Conference on Undergraduate Research 2015
Abbreviated title	ICUR 2015
Country/Territory	United States
City	Boise
Period	1/07/15 → …
Internet address	https://scholarworks.boisestate.edu/icur/2015/

EGS Disciplines

Biochemistry, Biophysics, and Structural Biology
Chemicals and Drugs
Other Immunology and Infectious Disease
Pathogenic Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "MTN Deficiency Attenuates Bacterial Biofilms and Adherence to the Extracellular Matrix",

abstract = " The enzyme methylthioadenosine nucleosidase (MTN) and its downstream pathways play a role in promoting many potent virulence phenotypes among gram negative bacterial pathogens. These phenotypes include both the formation of biofilms and adherence to mammalian extracellular matrix proteins (ECM) during infection that promote pathogenicity and infection. The role of MTN in these processes was examined by studying the effect of MTN inhibitors and genetic knock-out strains to reduce biofilms and ECM adherence in two model pathogens of Escherichia coli O157:H7 and Klebsiella pneumonia . The results of our studies indicate that deficiency of MTN activity decreases biofilms and ECM adherence, and supports virulence attenuation as a mechanism of action for MTN inhibitors.",

author = "Ally Isnor and Jason Stonick and Kenneth Cornell",

year = "2015",

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day = "1",

language = "American English",

note = "Idaho Conference on Undergraduate Research 2015, ICUR 2015 ; Conference date: 01-07-2015",

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TY - CONF

T1 - MTN Deficiency Attenuates Bacterial Biofilms and Adherence to the Extracellular Matrix

AU - Isnor, Ally

AU - Stonick, Jason

AU - Cornell, Kenneth

PY - 2015/7/1

Y1 - 2015/7/1

N2 - The enzyme methylthioadenosine nucleosidase (MTN) and its downstream pathways play a role in promoting many potent virulence phenotypes among gram negative bacterial pathogens. These phenotypes include both the formation of biofilms and adherence to mammalian extracellular matrix proteins (ECM) during infection that promote pathogenicity and infection. The role of MTN in these processes was examined by studying the effect of MTN inhibitors and genetic knock-out strains to reduce biofilms and ECM adherence in two model pathogens of Escherichia coli O157:H7 and Klebsiella pneumonia . The results of our studies indicate that deficiency of MTN activity decreases biofilms and ECM adherence, and supports virulence attenuation as a mechanism of action for MTN inhibitors.

AB - The enzyme methylthioadenosine nucleosidase (MTN) and its downstream pathways play a role in promoting many potent virulence phenotypes among gram negative bacterial pathogens. These phenotypes include both the formation of biofilms and adherence to mammalian extracellular matrix proteins (ECM) during infection that promote pathogenicity and infection. The role of MTN in these processes was examined by studying the effect of MTN inhibitors and genetic knock-out strains to reduce biofilms and ECM adherence in two model pathogens of Escherichia coli O157:H7 and Klebsiella pneumonia . The results of our studies indicate that deficiency of MTN activity decreases biofilms and ECM adherence, and supports virulence attenuation as a mechanism of action for MTN inhibitors.

UR - https://scholarworks.boisestate.edu/icur/2015/Poster_Session/74/

M3 - Poster

T2 - Idaho Conference on Undergraduate Research 2015

Y2 - 1 July 2015

ER -

MTN Deficiency Attenuates Bacterial Biofilms and Adherence to the Extracellular Matrix

Abstract

Conference

EGS Disciplines

UN SDGs

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