Multivalent Ions Control the Transport Through Lysenin Channels

Daniel Fologea; Eric Krueger; Redwan Al Faori; Rachel Lee; Yuriy I. Mazur; Ralph Henry; Mark Arnold; Greg J. Salamo

Multivalent Ions Control the Transport Through Lysenin Channels

Daniel Fologea, Eric Krueger, Redwan Al Faori, Rachel Lee, Yuriy I. Mazur, Ralph Henry, Mark Arnold, Greg J. Salamo

University of Arkansas

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.

Original language	American English
Journal	Biophysical Chemistry
Volume	152
Issue number	1-3
State	Published - Nov 2010
Externally published	Yes

Keywords

Ligand gated channels
Lysenin
Multivalent ions
Pore forming toxins

EGS Disciplines

Biophysics
Physics

Cite this

@article{fae7fa994dd24ad7ab709d878560f979,

title = "Multivalent Ions Control the Transport Through Lysenin Channels",

abstract = " We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.",

keywords = "Ligand gated channels, Lysenin, Multivalent ions, Pore forming toxins",

author = "Daniel Fologea and Eric Krueger and {Al Faori}, Redwan and Rachel Lee and Mazur, {Yuriy I.} and Ralph Henry and Mark Arnold and Salamo, {Greg J.}",

year = "2010",

month = nov,

language = "American English",

volume = "152",

number = "1-3",

}

TY - JOUR

T1 - Multivalent Ions Control the Transport Through Lysenin Channels

AU - Fologea, Daniel

AU - Krueger, Eric

AU - Al Faori, Redwan

AU - Lee, Rachel

AU - Mazur, Yuriy I.

AU - Henry, Ralph

AU - Arnold, Mark

AU - Salamo, Greg J.

PY - 2010/11

Y1 - 2010/11

N2 - We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.

AB - We report the effect of different ions on the conducting properties of lysenin channels inserted into planar lipid bilayer membranes. Our observations indicated that multivalent ions inhibited the lysenin channels conductance in a concentration dependent manner. The analysis performed on single channels revealed that multivalent ions induced reversible sub-conducting or closed states depending on the ionic charge and size. Good agreement is reported between experimental results and a theoretical model that is proposed to describe the interaction between divalent ions and lysenin channels as a simple isothermal absorption process.

KW - Ligand gated channels

KW - Lysenin

KW - Multivalent ions

KW - Pore forming toxins

UR - http://dx.doi.org/10.1016/j.bpc.2010.07.004

M3 - Article

C2 - 20724059

VL - 152

JO - Biophysical Chemistry

JF - Biophysical Chemistry

IS - 1-3

ER -

Multivalent Ions Control the Transport Through Lysenin Channels

Abstract

Keywords

EGS Disciplines

Other files and links

Fingerprint

Cite this