NMR Structure Determination of KTM: A Rationally Designed Alpha-Conotoxin Targeting Parkinson's-Relevant Receptor Isoforms

Leanna Marquart; Lisa Warner; Matthew King; Joe Dumais; Owen McDougal; Jim Groome

NMR Structure Determination of KTM: A Rationally Designed Alpha-Conotoxin Targeting Parkinson's-Relevant Receptor Isoforms

Leanna Marquart, Lisa Warner, Matthew King, Joe Dumais, Owen McDougal, Jim Groome

Chemistry Department

Research output: Contribution to conference › Presentation

1 Downloads (Pure)

Abstract

KTM is a rationally designed alpha-conotoxin predicted to have optimal binding affinity for the rat α3β2 nicotinic acetylcholine receptor isoform, a homology model for the human α6α4β2β3 receptor isoform implicated in Parkinson’s Disease. Validation of computational accuracy will help adjust computational parameters to give more accurate predictions of receptor binding, which are critical to receptor understanding and effective drug development for neurodegenerative diseases such as Parkinson’s. The NMR structure of KTM is currently being solved in order to validate computational results. Current progress indicates that the NMR structure follows the predicted structure well, but is not highly constrained.

Original language	American English
State	Published - 1800

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

NMR Structure Determination of KTM A Rationally Designed Alpha-CFinal published version, 961 KBLicense: Unspecified

Cite this

@conference{c7c78410ba9a4e599c27a671bba4f674,

title = "NMR Structure Determination of KTM: A Rationally Designed Alpha-Conotoxin Targeting Parkinson's-Relevant Receptor Isoforms",

abstract = " KTM is a rationally designed alpha-conotoxin predicted to have optimal binding affinity for the rat α3β2 nicotinic acetylcholine receptor isoform, a homology model for the human α6α4β2β3 receptor isoform implicated in Parkinson{\textquoteright}s Disease. Validation of computational accuracy will help adjust computational parameters to give more accurate predictions of receptor binding, which are critical to receptor understanding and effective drug development for neurodegenerative diseases such as Parkinson{\textquoteright}s. The NMR structure of KTM is currently being solved in order to validate computational results. Current progress indicates that the NMR structure follows the predicted structure well, but is not highly constrained.",

author = "Leanna Marquart and Lisa Warner and Matthew King and Joe Dumais and Owen McDougal and Jim Groome",

year = "1800",

language = "American English",

}

TY - CONF

T1 - NMR Structure Determination of KTM: A Rationally Designed Alpha-Conotoxin Targeting Parkinson's-Relevant Receptor Isoforms

AU - Marquart, Leanna

AU - Warner, Lisa

AU - King, Matthew

AU - Dumais, Joe

AU - McDougal, Owen

AU - Groome, Jim

PY - 1800

Y1 - 1800

N2 - KTM is a rationally designed alpha-conotoxin predicted to have optimal binding affinity for the rat α3β2 nicotinic acetylcholine receptor isoform, a homology model for the human α6α4β2β3 receptor isoform implicated in Parkinson’s Disease. Validation of computational accuracy will help adjust computational parameters to give more accurate predictions of receptor binding, which are critical to receptor understanding and effective drug development for neurodegenerative diseases such as Parkinson’s. The NMR structure of KTM is currently being solved in order to validate computational results. Current progress indicates that the NMR structure follows the predicted structure well, but is not highly constrained.

AB - KTM is a rationally designed alpha-conotoxin predicted to have optimal binding affinity for the rat α3β2 nicotinic acetylcholine receptor isoform, a homology model for the human α6α4β2β3 receptor isoform implicated in Parkinson’s Disease. Validation of computational accuracy will help adjust computational parameters to give more accurate predictions of receptor binding, which are critical to receptor understanding and effective drug development for neurodegenerative diseases such as Parkinson’s. The NMR structure of KTM is currently being solved in order to validate computational results. Current progress indicates that the NMR structure follows the predicted structure well, but is not highly constrained.

UR - https://scholarworks.boisestate.edu/gss_2019/18

M3 - Presentation

ER -

NMR Structure Determination of KTM: A Rationally Designed Alpha-Conotoxin Targeting Parkinson's-Relevant Receptor Isoforms

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this