TY - JOUR
T1 - Notch: A Multi-Functional Integrating System of Microenvironmental Signals
T2 - A multi-functional integrating system of microenvironmental signals
AU - LaFoya, Bryce
AU - Munroe, Jordan A.
AU - Mia, Masum M.
AU - Detweiler, Michael A.
AU - Crow, Jacob J.
AU - Wood, Travis
AU - Roth, Steven
AU - Albig, Allan R.
AU - Sharma, Bikram
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/15
Y1 - 2016/10/15
N2 - The Notch signaling cascade is an evolutionarily ancient system that allows cells to interact with their microenvironmental neighbors through direct cell-cell interactions, thereby directing a variety of developmental processes. Recent research is discovering that Notch signaling is also responsive to a broad variety of stimuli beyond cell-cell interactions, including: ECM composition, crosstalk with other signaling systems, shear stress, hypoxia, and hyperglycemia. Given this emerging understanding of Notch responsiveness to microenvironmental conditions, it appears that the classical view of Notch as a mechanism enabling cell-cell interactions, is only a part of a broader function to integrate microenvironmental cues. In this review, we summarize and discuss published data supporting the idea that the full function of Notch signaling is to serve as an integrator of microenvironmental signals thus allowing cells to sense and respond to a multitude of conditions around them.
AB - The Notch signaling cascade is an evolutionarily ancient system that allows cells to interact with their microenvironmental neighbors through direct cell-cell interactions, thereby directing a variety of developmental processes. Recent research is discovering that Notch signaling is also responsive to a broad variety of stimuli beyond cell-cell interactions, including: ECM composition, crosstalk with other signaling systems, shear stress, hypoxia, and hyperglycemia. Given this emerging understanding of Notch responsiveness to microenvironmental conditions, it appears that the classical view of Notch as a mechanism enabling cell-cell interactions, is only a part of a broader function to integrate microenvironmental cues. In this review, we summarize and discuss published data supporting the idea that the full function of Notch signaling is to serve as an integrator of microenvironmental signals thus allowing cells to sense and respond to a multitude of conditions around them.
UR - https://scholarworks.boisestate.edu/bio_facpubs/474
UR - http://dx.doi.org/10.1016/j.ydbio.2016.08.023
UR - http://www.scopus.com/inward/record.url?scp=84992523471&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2016.08.023
DO - 10.1016/j.ydbio.2016.08.023
M3 - Article
C2 - 27565024
VL - 418
SP - 227
EP - 241
JO - History Faculty Publications and Presentations
JF - History Faculty Publications and Presentations
IS - 2
ER -