TY - GEN
T1 - Operation of a DNA-Based Autocatalytic Network in Serum
AU - Graugnard, Elton
AU - Cox, Amber
AU - Lee, Jeunghoon
AU - Jorcyk, Cheryl
AU - Yurke, Bernard
AU - Hughes, William L.
PY - 2011
Y1 - 2011
N2 - The potential for inferring the presence of cancer by the detection of miRNA in human blood has motivated research into the design and operation of DNA-based chemical amplifiers that can operate in bodily fluids. As a first step toward this goal, we have tested the operation of a DNA-based autocatalytic network in human serum and mouse serum. With the addition of sodium dodecyl sulfate to prevent degradation by nuclease activity, the network was found to operate successfully with both DNA and RNA catalysts.
AB - The potential for inferring the presence of cancer by the detection of miRNA in human blood has motivated research into the design and operation of DNA-based chemical amplifiers that can operate in bodily fluids. As a first step toward this goal, we have tested the operation of a DNA-based autocatalytic network in human serum and mouse serum. With the addition of sodium dodecyl sulfate to prevent degradation by nuclease activity, the network was found to operate successfully with both DNA and RNA catalysts.
UR - http://www.scopus.com/inward/record.url?scp=79251561216&partnerID=8YFLogxK
UR - https://scholarworks.boisestate.edu/mse_facpubs/19
U2 - 10.1007/978-3-642-18305-8
DO - 10.1007/978-3-642-18305-8
M3 - Conference contribution
SN - 9783642183041
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 83
EP - 88
BT - DNA'10 Proceedings of the 16th International Conference on DNA Computing and Molecular Programming
T2 - 16th International Conference on DNA Computing and Molecular Programming, DNA 16
Y2 - 14 June 2010 through 17 June 2010
ER -
