TY - JOUR
T1 - Phase Diagram of a Ternary Mixture of Cholesterol and Saturated and Unsaturated Lipids Calculated from a Microscopic Model
AU - Elliott, R.
AU - Szleifer, I.
AU - Schick, M.
N1 - We employ a molecular model to study a ternary mixture of saturated lipid, with tails of 16 carbons, a monounsaturated lipid with tails of 18 carbons, and cholesterol. The model, solved within mean-field theory, produces several forms of phase diagrams depending upon the relative strengths of interactions, but only one that shows the coexistence of two liquid phases observed in experiment.
PY - 2006/3/6
Y1 - 2006/3/6
N2 - We employ a molecular model to study a ternary mixture of saturated lipid, with tails of 16 carbons, a monounsaturated lipid with tails of 18 carbons, and cholesterol. The model, solved within mean-field theory, produces several forms of phase diagrams depending upon the relative strengths of interactions, but only one that shows the coexistence of two liquid phases observed in experiment. The lipids in the phase rich in cholesterol are more ordered than those in the other. The binary cholesterol, saturated lipid system also exhibits liquid, liquid coexistence.
AB - We employ a molecular model to study a ternary mixture of saturated lipid, with tails of 16 carbons, a monounsaturated lipid with tails of 18 carbons, and cholesterol. The model, solved within mean-field theory, produces several forms of phase diagrams depending upon the relative strengths of interactions, but only one that shows the coexistence of two liquid phases observed in experiment. The lipids in the phase rich in cholesterol are more ordered than those in the other. The binary cholesterol, saturated lipid system also exhibits liquid, liquid coexistence.
UR - https://doi.org/10.1103/PhysRevLett.96.098101
U2 - 10.1103/PhysRevLett.96.098101
DO - 10.1103/PhysRevLett.96.098101
M3 - Article
VL - 96
JO - Physical Review Letters
JF - Physical Review Letters
IS - 9
ER -