Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls

Janet Rubin, Maya Styner, Gunes Uzer

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalExercise and Sport Sciences Reviews
Volume46
Issue number1
DOIs
StatePublished - 1 Jan 2018

Keywords

  • actin
  • adipocyte
  • Arp2/3
  • LINC complex
  • osteoblast
  • stem cell
  • telomere

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