Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls

Janet Rubin; Maya Styner; Gunes Uzer

doi:10.1249/JES.0000000000000129

Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls

Janet Rubin
, Maya Styner
, Gunes Uzer

Mechanical and Biomedical Engineering Department

University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Exercise and Sport Sciences Reviews
Volume	46
Issue number	1
DOIs	https://doi.org/10.1249/JES.0000000000000129
State	Published - 1 Jan 2018

Keywords

Arp2/3
LINC complex
actin
adipocyte
osteoblast
stem cell
telomere

Access to Document

10.1249/JES.0000000000000129

Cite this

@article{8d784697110648589f5f6814f257bd7b,

title = "Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls",

abstract = "Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.",

keywords = "Arp2/3, LINC complex, actin, adipocyte, osteoblast, stem cell, telomere",

author = "Janet Rubin and Maya Styner and Gunes Uzer",

note = "Publisher Copyright: {\textcopyright} Lippincott Williams \& Wilkins.",

year = "2018",

month = jan,

day = "1",

doi = "10.1249/JES.0000000000000129",

language = "English",

volume = "46",

pages = "42--47",

number = "1",

}

TY - JOUR

T1 - Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls

AU - Rubin, Janet

AU - Styner, Maya

AU - Uzer, Gunes

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

AB - Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

KW - Arp2/3

KW - LINC complex

KW - actin

KW - adipocyte

KW - osteoblast

KW - stem cell

KW - telomere

UR - https://www.scopus.com/pages/publications/85038230957

U2 - 10.1249/JES.0000000000000129

DO - 10.1249/JES.0000000000000129

M3 - Article

C2 - 28795956

AN - SCOPUS:85038230957

SN - 0091-6331

VL - 46

SP - 42

EP - 47

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 1

ER -

Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this