Progress and Perspectives in Plant Sterol and Plant Stanol Research

Peter J.H. Jones; Maryam Shamloo; Dylan S. MacKay; Todd C. Rideout; Semone B. Myrie; Jogchum Plat; Jean-baptiste O. Roullet; David J. Baer; Kara L. Calkins; Harry R. Davis; P. Barton Duell; Henry Ginsberg; Helena Gylling; David Jenkins; Dieter Lütjohann; Mohammad Moghadasian; Robert A. Moreau; David Mymin; Richard E. Ostlund; Rouyanne T. Ras; Javier Ochoa-Reparaz; Elke A. Trautwein; Stephen Turley; Tim Vanmierlo; Oliver Weingärtner

doi:10.1093/nutrit/nuy032

Progress and Perspectives in Plant Sterol and Plant Stanol Research

Peter J.H. Jones
, Maryam Shamloo
, Dylan S. MacKay
, Todd C. Rideout
, Semone B. Myrie
, Jogchum Plat
, Jean-baptiste O. Roullet
, David J. Baer
, Kara L. Calkins
, Harry R. Davis
, P. Barton Duell
, Henry Ginsberg
, Helena Gylling
, David Jenkins
, Dieter Lütjohann
, Mohammad Moghadasian
, Robert A. Moreau
, David Mymin
, Richard E. Ostlund
, Rouyanne T. Ras

Javier Ochoa-Reparaz, Elke A. Trautwein, Stephen Turley, Tim Vanmierlo, Oliver Weingärtner

University of Manitoba
University of Buffalo
Maastricht University
Oregon Health and Science University
U.S. Department of Agriculture
University of California at Los Angeles
CVPath Institute, Inc.
Columbia University
University of Helsinki
Helsinki University Central Hospital
University of Toronto
St. Michael’s Hospital
University of Bonn
Washington University St. Louis
Unilever Research and Development Vlaardingen
Eastern Washington University
University of Texas Southwestern Medical Center
Hasselt University
Friedrich Schiller University Jena

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

Original language	American English
Pages (from-to)	725-746
Number of pages	22
Journal	Nutrition Reviews
Volume	76
Issue number	10
DOIs	https://doi.org/10.1093/nutrit/nuy032
State	Published - Oct 2018
Externally published	Yes

Keywords

cholesterol
nutrition
phytosterols
plant stanols
plant sterols
sitosterolemia

EGS Disciplines

Biology

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10.1093/nutrit/nuy032License: Unspecified

Cite this

Jones, P. J. H., Shamloo, M., MacKay, D. S., Rideout, T. C., Myrie, S. B., Plat, J., Roullet, J. O., Baer, D. J., Calkins, K. L., Davis, H. R., Duell, P. B., Ginsberg, H., Gylling, H., Jenkins, D., Lütjohann, D., Moghadasian, M., Moreau, R. A., Mymin, D., Ostlund, R. E., ... Weingärtner, O. (2018). Progress and Perspectives in Plant Sterol and Plant Stanol Research. Nutrition Reviews, 76(10), 725-746. https://doi.org/10.1093/nutrit/nuy032

@article{19f30d43e2d34d71ac13c5d2c37ea04f,

title = "Progress and Perspectives in Plant Sterol and Plant Stanol Research",

abstract = " Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking. ",

keywords = "cholesterol, nutrition, phytosterols, plant stanols, plant sterols, sitosterolemia",

author = "Jones, \{Peter J.H.\} and Maryam Shamloo and MacKay, \{Dylan S.\} and Rideout, \{Todd C.\} and Myrie, \{Semone B.\} and Jogchum Plat and Roullet, \{Jean-baptiste O.\} and Baer, \{David J.\} and Calkins, \{Kara L.\} and Davis, \{Harry R.\} and Duell, \{P. Barton\} and Henry Ginsberg and Helena Gylling and David Jenkins and Dieter L{\"u}tjohann and Mohammad Moghadasian and Moreau, \{Robert A.\} and David Mymin and Ostlund, \{Richard E.\} and Ras, \{Rouyanne T.\} and Javier Ochoa-Reparaz and Trautwein, \{Elke A.\} and Stephen Turley and Tim Vanmierlo and Oliver Weing{\"a}rtner",

note = "Plant sterols/stanols have been examined across multiple food formats, and there is no apparent difference in their cholesterol-lowering efficacy in high-fat vs lowfat or nonfat foods., In terms of the type of carrier fat, a recent study found no difference between different types of carrier fats in the relative reduction in LDL-C levels. Jones, Peter J.H.; Shamloo, Maryam; MacKay, Dylan S.; Rideout, Todd C.; Myrie, Semone B.; Plat, Jogchum; . . . and Weing{\"a}rtner, Oliver. (2018). {"}Progress and Perspectives in Plant Sterol and Plant Stanol Research{"}. Nutrition Reviews, 76(10), 725-746.",

year = "2018",

month = oct,

doi = "10.1093/nutrit/nuy032",

language = "American English",

volume = "76",

pages = "725--746",

number = "10",

}

Jones, PJH, Shamloo, M, MacKay, DS, Rideout, TC, Myrie, SB, Plat, J, Roullet, JO, Baer, DJ, Calkins, KL, Davis, HR, Duell, PB, Ginsberg, H, Gylling, H, Jenkins, D, Lütjohann, D, Moghadasian, M, Moreau, RA, Mymin, D, Ostlund, RE, Ras, RT, Ochoa-Reparaz, J, Trautwein, EA, Turley, S, Vanmierlo, T & Weingärtner, O 2018, 'Progress and Perspectives in Plant Sterol and Plant Stanol Research', Nutrition Reviews, vol. 76, no. 10, pp. 725-746. https://doi.org/10.1093/nutrit/nuy032

TY - JOUR

T1 - Progress and Perspectives in Plant Sterol and Plant Stanol Research

AU - Jones, Peter J.H.

AU - Shamloo, Maryam

AU - MacKay, Dylan S.

AU - Rideout, Todd C.

AU - Myrie, Semone B.

AU - Plat, Jogchum

AU - Roullet, Jean-baptiste O.

AU - Baer, David J.

AU - Calkins, Kara L.

AU - Davis, Harry R.

AU - Duell, P. Barton

AU - Ginsberg, Henry

AU - Gylling, Helena

AU - Jenkins, David

AU - Lütjohann, Dieter

AU - Moghadasian, Mohammad

AU - Moreau, Robert A.

AU - Mymin, David

AU - Ostlund, Richard E.

AU - Ras, Rouyanne T.

AU - Ochoa-Reparaz, Javier

AU - Trautwein, Elke A.

AU - Turley, Stephen

AU - Vanmierlo, Tim

AU - Weingärtner, Oliver

N1 - Plant sterols/stanols have been examined across multiple food formats, and there is no apparent difference in their cholesterol-lowering efficacy in high-fat vs lowfat or nonfat foods., In terms of the type of carrier fat, a recent study found no difference between different types of carrier fats in the relative reduction in LDL-C levels. Jones, Peter J.H.; Shamloo, Maryam; MacKay, Dylan S.; Rideout, Todd C.; Myrie, Semone B.; Plat, Jogchum; . . . and Weingärtner, Oliver. (2018). "Progress and Perspectives in Plant Sterol and Plant Stanol Research". Nutrition Reviews, 76(10), 725-746.

PY - 2018/10

Y1 - 2018/10

N2 - Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

AB - Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

KW - cholesterol

KW - nutrition

KW - phytosterols

KW - plant stanols

KW - plant sterols

KW - sitosterolemia

U2 - 10.1093/nutrit/nuy032

DO - 10.1093/nutrit/nuy032

M3 - Article

C2 - 30101294

VL - 76

SP - 725

EP - 746

JO - Nutrition Reviews

JF - Nutrition Reviews

IS - 10

ER -

Progress and Perspectives in Plant Sterol and Plant Stanol Research

Abstract

Keywords

EGS Disciplines

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