Quantifying analytes in paper-based microfluidic devices without using external electronic readers

Gregory G. Lewis; Matthew J. Ditucci; Scott T. Phillips

doi:10.1002/anie.201207239

Quantifying analytes in paper-based microfluidic devices without using external electronic readers

Gregory G. Lewis
, Matthew J. Ditucci
, Scott T. Phillips

Micron School of Materials Science and Engineering

Pennsylvania State University

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

A matter of time: Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1) reacts with a desired analyte to produce hydrophilic products. This change in wetting properties enables selective and quantitative detection of the analyte.

Original language	English
Pages (from-to)	12707-12710
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	51
DOIs	https://doi.org/10.1002/anie.201207239
State	Published - 14 Dec 2012

Keywords

analytical methods
microfluidics
paper diagnostic
point-of-care assays
sensors

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10.1002/anie.201207239

Cite this

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abstract = "A matter of time: Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1) reacts with a desired analyte to produce hydrophilic products. This change in wetting properties enables selective and quantitative detection of the analyte.",

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AB - A matter of time: Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1) reacts with a desired analyte to produce hydrophilic products. This change in wetting properties enables selective and quantitative detection of the analyte.

KW - analytical methods

KW - microfluidics

KW - paper diagnostic

KW - point-of-care assays

KW - sensors

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JO - Angewandte Chemie - International Edition

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Quantifying analytes in paper-based microfluidic devices without using external electronic readers

Abstract

Keywords

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