Quantifying Distortion Energy in Collagen Matrices Subjected to Complex Loads Using a Biaxial Bioreactor

Katie Hollar, Danielle Siegel, John Everingham, Abdullah Ahmad, Alvaro Morfin, Gunes Uzer, Trevor Lujan

Research output: Contribution to conferencePresentation

Abstract

To test mechanobiology theories, bioreactors are used to apply various loads to cellularized constructs. A novel application of biaxial bioreactors is to apply controlled states of stress to study the effect of strain energy (hydrostatic and distortion) on cellular behavior. The research objective was to validate a method of subjecting 3D constructs to differing magnitudes of distortion while maintaining a targeted strain energy. The bioreactor was able to apply a single magnitude of strain energy with an average error of 4 ± 3%. To our knowledge, this is the first study to control total strain energy in a 3D construct.

Original languageAmerican English
StatePublished - 12 Apr 2019

Fingerprint

Dive into the research topics of 'Quantifying Distortion Energy in Collagen Matrices Subjected to Complex Loads Using a Biaxial Bioreactor'. Together they form a unique fingerprint.

Cite this