Radiation-triggered liposomes

Daniel Fologea

Radiation-triggered liposomes

Daniel Fologea (Inventor)

Physics Department

Research output: Patent

Abstract

The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.

Original language	American English
Patent number	US-12208138-B2
IPC	A61K41/00 (20200101); A61K9/127 (20060101); A61K38/16 (20060101); A61K38/17 (20060101); A61N5/06 (20060101); A61N5/10 (20060101) U.S. Cl.:
Filing date	18/02/18
State	Published - 31 Dec 2020

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title = "Radiation-triggered liposomes",

abstract = "The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.",

author = "Daniel Fologea",

year = "2020",

month = dec,

day = "31",

language = "American English",

publisher = "United States Patent and Trademark Office",

address = "United States",

type = "Patent",

note = "US-12208138-B2; A61K41/00 (20200101); A61K9/127 (20060101); A61K38/16 (20060101); A61K38/17 (20060101); A61N5/06 (20060101); A61N5/10 (20060101) U.S. Cl.:",

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TY - PAT

T1 - Radiation-triggered liposomes

AU - Fologea, Daniel

PY - 2020/12/31

Y1 - 2020/12/31

N2 - The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.

AB - The present disclosure is directed to radiation triggered liposomes and their use in delivery and release of pharmaceutical drugs upon exposure to ionizing radiation. In one embodiment liposomes are provided that comprise cholesterol and sphingolipids modified to comprise reactive groups that are activated by ionizing radiation to form crosslinks with other lipids of the liposome causing the release of the liposomal contents.

M3 - Patent

M1 - US-12208138-B2

Y2 - 2018/02/18

PB - United States Patent and Trademark Office

ER -

Radiation-triggered liposomes

Abstract

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