TY - JOUR
T1 - Renal hemodynamic responses to dynamic exercise in rabbits
AU - Mueller, Patrick J.
AU - O'Hagan, Kathleen P.
AU - Skogg, Kara A.
AU - Buckwalter, John B.
AU - Clifford, Philip S.
PY - 1998/11
Y1 - 1998/11
N2 - Cardiovascular hemodynamics, including renal blood flow, were measured in rabbits with one intact and one denervated kidney during various intensities of treadmill exercise. Within the first 10 s of exercise, there was rapid vasoconstriction in the innervated kidney associated with decreases in renal blood flow (range -10 to -17%). The vasoconstriction in the innervated kidney was evident at all workloads and was intensity dependent. There was no significant vasoconstriction or change in renal blood flow (range 0.5 to -3.1%) in the denervated kidney at the onset of exercise. However, a slowly developing vasoconstriction occurred in the denervated kidney as exercise progressed to 2 rain at all workloads. Examination of responses to exercise performed under α-adrenergic blockade with phentolamine (5 mg/kg iv) revealed that the vasoconstriction in the innervated kidney at the onset of exercise and the delayed vasoconstriction in the denervated kidney were due primarily to activation of α-adrenergic receptors. In addition, a residual vasoconstriction was also present in the innervated kidney after α-adrenergic blockade, suggesting that, during exercise, activation of other renal vasoconstrictor mechanisms occurs which is dependent on the presence of renal nerves.
AB - Cardiovascular hemodynamics, including renal blood flow, were measured in rabbits with one intact and one denervated kidney during various intensities of treadmill exercise. Within the first 10 s of exercise, there was rapid vasoconstriction in the innervated kidney associated with decreases in renal blood flow (range -10 to -17%). The vasoconstriction in the innervated kidney was evident at all workloads and was intensity dependent. There was no significant vasoconstriction or change in renal blood flow (range 0.5 to -3.1%) in the denervated kidney at the onset of exercise. However, a slowly developing vasoconstriction occurred in the denervated kidney as exercise progressed to 2 rain at all workloads. Examination of responses to exercise performed under α-adrenergic blockade with phentolamine (5 mg/kg iv) revealed that the vasoconstriction in the innervated kidney at the onset of exercise and the delayed vasoconstriction in the denervated kidney were due primarily to activation of α-adrenergic receptors. In addition, a residual vasoconstriction was also present in the innervated kidney after α-adrenergic blockade, suggesting that, during exercise, activation of other renal vasoconstrictor mechanisms occurs which is dependent on the presence of renal nerves.
KW - Phentolamine
KW - Renal blood flow
KW - Renal denervation
KW - Renal nerves
KW - α-adrenergic receptors
UR - http://www.scopus.com/inward/record.url?scp=0031737655&partnerID=8YFLogxK
U2 - 10.1152/jappl.1998.85.5.1605
DO - 10.1152/jappl.1998.85.5.1605
M3 - Article
C2 - 9804559
AN - SCOPUS:0031737655
SN - 8750-7587
VL - 85
SP - 1605
EP - 1614
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 5
ER -