Renal hemodynamic responses to dynamic exercise in rabbits

Patrick J. Mueller, Kathleen P. O'Hagan, Kara A. Skogg, John B. Buckwalter, Philip S. Clifford

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Cardiovascular hemodynamics, including renal blood flow, were measured in rabbits with one intact and one denervated kidney during various intensities of treadmill exercise. Within the first 10 s of exercise, there was rapid vasoconstriction in the innervated kidney associated with decreases in renal blood flow (range -10 to -17%). The vasoconstriction in the innervated kidney was evident at all workloads and was intensity dependent. There was no significant vasoconstriction or change in renal blood flow (range 0.5 to -3.1%) in the denervated kidney at the onset of exercise. However, a slowly developing vasoconstriction occurred in the denervated kidney as exercise progressed to 2 rain at all workloads. Examination of responses to exercise performed under α-adrenergic blockade with phentolamine (5 mg/kg iv) revealed that the vasoconstriction in the innervated kidney at the onset of exercise and the delayed vasoconstriction in the denervated kidney were due primarily to activation of α-adrenergic receptors. In addition, a residual vasoconstriction was also present in the innervated kidney after α-adrenergic blockade, suggesting that, during exercise, activation of other renal vasoconstrictor mechanisms occurs which is dependent on the presence of renal nerves.

Original languageEnglish
Pages (from-to)1605-1614
Number of pages10
JournalJournal of Applied Physiology
Volume85
Issue number5
DOIs
StatePublished - Nov 1998
Externally publishedYes

Keywords

  • Phentolamine
  • Renal blood flow
  • Renal denervation
  • Renal nerves
  • α-adrenergic receptors

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