TY - JOUR
T1 - Repurposing Drugs to Treat Heart and Brain Illness
AU - Cantrell, Maranda S.
AU - Soto-Avellaneda, Alejandro
AU - Wall, Jackson D.
AU - Ajeti, Aaron D.
AU - Morrison, Brad E.
AU - Warner, Lisa R.
AU - McDougal, Owen M.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Drug development is a complicated, slow and expensive process with high failure rates. One strategy to mitigate these factors is to recycle existing drugs with viable safety profiles and have gained Food and Drug Administration approval following extensive clinical trials. Cardiovascular and neurodegenerative diseases are difficult to treat, and there exist few effective therapeutics, necessitating the development of new, more efficacious drugs. Recent scientific studies have led to a mechanistic understanding of heart and brain disease progression, which has led researchers to assess myriad drugs for their potential as pharmacological treatments for these ailments. The focus of this review is to survey strategies for the selection of drug repurposing candidates and provide representative case studies where drug repurposing strategies were used to discover therapeutics for cardiovascular and neurodegenerative diseases, with a focus on anti-inflammatory processes where new drug alternatives are needed.
AB - Drug development is a complicated, slow and expensive process with high failure rates. One strategy to mitigate these factors is to recycle existing drugs with viable safety profiles and have gained Food and Drug Administration approval following extensive clinical trials. Cardiovascular and neurodegenerative diseases are difficult to treat, and there exist few effective therapeutics, necessitating the development of new, more efficacious drugs. Recent scientific studies have led to a mechanistic understanding of heart and brain disease progression, which has led researchers to assess myriad drugs for their potential as pharmacological treatments for these ailments. The focus of this review is to survey strategies for the selection of drug repurposing candidates and provide representative case studies where drug repurposing strategies were used to discover therapeutics for cardiovascular and neurodegenerative diseases, with a focus on anti-inflammatory processes where new drug alternatives are needed.
KW - drug repurposing
KW - drug development
KW - cardiovascular disease
KW - neurogenerative disease
KW - inflammation
KW - drug repositioning
KW - Neurodegenerative disease
UR - https://scholarworks.boisestate.edu/chem_facpubs/143
UR - http://www.scopus.com/inward/record.url?scp=85108893458&partnerID=8YFLogxK
U2 - 10.3390/ph14060573
DO - 10.3390/ph14060573
M3 - Article
VL - 14
JO - Chemistry and Biochemistry Faculty Publications and Presentations
JF - Chemistry and Biochemistry Faculty Publications and Presentations
IS - 6
M1 - 573
ER -