Repurposing Drugs to Treat Heart and Brain Illness

Maranda S. Cantrell, Alejandro Soto-Avellaneda, Jackson D. Wall, Aaron D. Ajeti, Brad E. Morrison, Lisa R. Warner, Owen M. McDougal

Research output: Contribution to journalArticlepeer-review

4 Scopus citations
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Abstract

Drug development is a complicated, slow and expensive process with high failure rates. One strategy to mitigate these factors is to recycle existing drugs with viable safety profiles and have gained Food and Drug Administration approval following extensive clinical trials. Cardiovascular and neurodegenerative diseases are difficult to treat, and there exist few effective therapeutics, necessitating the development of new, more efficacious drugs. Recent scientific studies have led to a mechanistic understanding of heart and brain disease progression, which has led researchers to assess myriad drugs for their potential as pharmacological treatments for these ailments. The focus of this review is to survey strategies for the selection of drug repurposing candidates and provide representative case studies where drug repurposing strategies were used to discover therapeutics for cardiovascular and neurodegenerative diseases, with a focus on anti-inflammatory processes where new drug alternatives are needed.

Original languageAmerican English
Article number573
JournalChemistry and Biochemistry Faculty Publications and Presentations
Volume14
Issue number6
DOIs
StatePublished - 1 Jun 2021

Keywords

  • drug repurposing
  • drug development
  • cardiovascular disease
  • neurogenerative disease
  • inflammation
  • drug repositioning
  • Neurodegenerative disease

EGS Disciplines

  • Chemistry
  • Pharmacy and Pharmaceutical Sciences

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