TY - JOUR
T1 - Serotonin and self-control
T2 - A genetically moderated stress sensitization effect
AU - Boisvert, Danielle
AU - Wells, Jessica
AU - Armstrong, Todd A.
AU - Lewis, Richard H.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Purpose: The current study seeks to examine how two widely studied serotonergic polymorphisms, MAOA-uVNTR and 5-HTTLPR, interact with early and later life stressors to explain between-individual variation in low self-control in a genetically moderated stress sensitization model (G × E × E). Methods: Using a sample of male undergraduate students (n = 190), regression analyses were performed to examine three-way interactions of distal and proximal stress by MAOA-uVNTR and 5-HTTLPR separately, while controlling for age, race, parenting, and peer delinquency. Results: Results suggest that MAOA-uVNTR and 5-HTTLPR polymorphisms moderate individual stress sensitization in the explanation of self-control. Conclusion: Our findings highlight the need to study the etiology of self-control from both developmental and biological perspectives by demonstrating that molecular genetic variation related to serotonergic function interacts with distal stressors to increase reactivity to proximal stressors.
AB - Purpose: The current study seeks to examine how two widely studied serotonergic polymorphisms, MAOA-uVNTR and 5-HTTLPR, interact with early and later life stressors to explain between-individual variation in low self-control in a genetically moderated stress sensitization model (G × E × E). Methods: Using a sample of male undergraduate students (n = 190), regression analyses were performed to examine three-way interactions of distal and proximal stress by MAOA-uVNTR and 5-HTTLPR separately, while controlling for age, race, parenting, and peer delinquency. Results: Results suggest that MAOA-uVNTR and 5-HTTLPR polymorphisms moderate individual stress sensitization in the explanation of self-control. Conclusion: Our findings highlight the need to study the etiology of self-control from both developmental and biological perspectives by demonstrating that molecular genetic variation related to serotonergic function interacts with distal stressors to increase reactivity to proximal stressors.
KW - 5-HTTLPR
KW - Low self-control
KW - MAOA-uVNTR
KW - Stress sensitization
UR - http://www.scopus.com/inward/record.url?scp=85025477626&partnerID=8YFLogxK
U2 - 10.1016/j.jcrimjus.2017.07.008
DO - 10.1016/j.jcrimjus.2017.07.008
M3 - Article
AN - SCOPUS:85025477626
SN - 0047-2352
VL - 56
SP - 98
EP - 106
JO - Journal of Criminal Justice
JF - Journal of Criminal Justice
ER -