TY - JOUR
T1 - Signaling and Other Functions of Lipids in Autophagy: A Review
T2 - A review
AU - Soto-Avellaneda, Alejandro
AU - Morrison, Brad E.
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/9/30
Y1 - 2020/9/30
N2 - The process of autophagy is integral to cellular function. In this process, proteins, organelles, and metabolites are engulfed in a lipid vesicle and trafficked to a lysosome for degradation. Its central role in protein and organelle homeostasis has piqued interest for autophagy dysfunction as a driver of pathology for a number of diseases including cancer, muscular disorders, neurological disorders, and non-alcoholic fatty liver disease. For much of its history, the study of autophagy has centered around proteins, however, due to advances in mass spectrometry and refined methodologies, the role of lipids in this essential cellular process has become more apparent. This review discusses the diverse endogenous lipid compounds shown to mediate autophagy. Downstream lipid signaling pathways are also reviewed in the context of autophagy regulation. Specific focus is placed upon the Mammalian Target of Rapamycin (mTOR) and Peroxisome Proliferator-Activated Receptor (PPAR) signaling pathways as integration hubs for lipid regulation of autophagy.
AB - The process of autophagy is integral to cellular function. In this process, proteins, organelles, and metabolites are engulfed in a lipid vesicle and trafficked to a lysosome for degradation. Its central role in protein and organelle homeostasis has piqued interest for autophagy dysfunction as a driver of pathology for a number of diseases including cancer, muscular disorders, neurological disorders, and non-alcoholic fatty liver disease. For much of its history, the study of autophagy has centered around proteins, however, due to advances in mass spectrometry and refined methodologies, the role of lipids in this essential cellular process has become more apparent. This review discusses the diverse endogenous lipid compounds shown to mediate autophagy. Downstream lipid signaling pathways are also reviewed in the context of autophagy regulation. Specific focus is placed upon the Mammalian Target of Rapamycin (mTOR) and Peroxisome Proliferator-Activated Receptor (PPAR) signaling pathways as integration hubs for lipid regulation of autophagy.
KW - autophagy
KW - fatty acids
KW - lipids
KW - mammalian target of rapamycin
KW - peroxisome proliferator-activated receptor
KW - phospholipids
KW - Sphingolipids
UR - https://scholarworks.boisestate.edu/bio_facpubs/625
UR - http://www.scopus.com/inward/record.url?scp=85092480691&partnerID=8YFLogxK
U2 - 10.1186/s12944-020-01389-2
DO - 10.1186/s12944-020-01389-2
M3 - Article
C2 - 32998777
VL - 19
JO - History Faculty Publications and Presentations
JF - History Faculty Publications and Presentations
IS - 1
M1 - 214
ER -