TY - JOUR
T1 - Space radiation alters genotype-phenotype correlations in fear learning and memory tests
AU - Iancu, Ovidiu Dan
AU - Boutros, Sydney Weber
AU - Olsen, Reid H.J.
AU - Davis, Matthew J.
AU - Stewart, Blair
AU - Eiwaz, Massarra
AU - Marzulla, Tessa
AU - Belknap, John
AU - Fallgren, Christina M.
AU - Edmondson, Elijah F.
AU - Weil, Michael M.
AU - Raber, Jacob
N1 - Publisher Copyright:
© 2018 Iancu, Boutros, Olsen, Davis, Stewart, Eiwaz, Marzulla, Belknap, Fallgren, Edmondson, Weil and Raber.
PY - 2018/10/9
Y1 - 2018/10/9
N2 - Behavioral and cognitive traits have a genetic component even though contributions from individual genes and genomic loci are in many cases modest. Changes in the environment can alter genotype-phenotype relationships. Space travel, which includes exposure to ionizing radiation, constitutes environmental challenges and is expected to induce not only dramatic behavioral and cognitive changes but also has the potential to induce physical DNA damage. In this study, we utilized a genetically heterogeneous mouse model, dense genotype data, and shifting environmental challenges, including ionizing radiation exposure, to explore and quantify the size and stability of the genetic component of fear learning and memory-related measures. Exposure to ionizing radiation and other external stressors altered the genotype-phenotype correlations, although different behavioral and cognitive measures were affected to different extents. Utilizing an integrative genomic approach, we identified pathways and functional ontology categories associated with these behavioral and cognitive measures.
AB - Behavioral and cognitive traits have a genetic component even though contributions from individual genes and genomic loci are in many cases modest. Changes in the environment can alter genotype-phenotype relationships. Space travel, which includes exposure to ionizing radiation, constitutes environmental challenges and is expected to induce not only dramatic behavioral and cognitive changes but also has the potential to induce physical DNA damage. In this study, we utilized a genetically heterogeneous mouse model, dense genotype data, and shifting environmental challenges, including ionizing radiation exposure, to explore and quantify the size and stability of the genetic component of fear learning and memory-related measures. Exposure to ionizing radiation and other external stressors altered the genotype-phenotype correlations, although different behavioral and cognitive measures were affected to different extents. Utilizing an integrative genomic approach, we identified pathways and functional ontology categories associated with these behavioral and cognitive measures.
KW - Behavioral genetics
KW - Fear learning and memory
KW - Genotype-phenotype
KW - Mice
KW - Space radiation
UR - http://www.scopus.com/inward/record.url?scp=85055353600&partnerID=8YFLogxK
U2 - 10.3389/fgene.2018.00404
DO - 10.3389/fgene.2018.00404
M3 - Article
AN - SCOPUS:85055353600
VL - 9
JO - Frontiers in Genetics
JF - Frontiers in Genetics
IS - OCT
M1 - 404
ER -