Systems chemistry on ribozyme self-construction: Evidence for anabolic autocatalysis in a recombination network

Eric J. Hayden; Günter von Kiedrowski; Niles Lehman

doi:10.1002/anie.200802177

Systems chemistry on ribozyme self-construction: Evidence for anabolic autocatalysis in a recombination network

Eric J. Hayden, Günter von Kiedrowski, Niles Lehman

Portland State University

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Humpty Dumpty, heal thyself: Four fragments of a catalytic RNA can autocatalytically self-assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points. (Figure Presented)

Original language	American English
Pages (from-to)	8424-8428
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	44
DOIs	https://doi.org/10.1002/anie.200802177
State	Published - 20 Oct 2008
Externally published	Yes

Keywords

Autocatalysis
Origin of life
Ribozymes
RNA
Self-assembly

EGS Disciplines

Biochemistry
Biology

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10.1002/anie.200802177

Cite this

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title = "Systems chemistry on ribozyme self-construction: Evidence for anabolic autocatalysis in a recombination network",

abstract = "Humpty Dumpty, heal thyself: Four fragments of a catalytic RNA can autocatalytically self-assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points. (Figure Presented)",

keywords = "Autocatalysis, Origin of life, Ribozymes, RNA, Self-assembly",

author = "Hayden, \{Eric J.\} and G{\"u}nter von Kiedrowski and Niles Lehman",

year = "2008",

month = oct,

day = "20",

doi = "10.1002/anie.200802177",

language = "American English",

volume = "47",

pages = "8424--8428",

number = "44",

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TY - JOUR

T1 - Systems chemistry on ribozyme self-construction

T2 - Evidence for anabolic autocatalysis in a recombination network

AU - Hayden, Eric J.

AU - von Kiedrowski, Günter

AU - Lehman, Niles

PY - 2008/10/20

Y1 - 2008/10/20

N2 - Humpty Dumpty, heal thyself: Four fragments of a catalytic RNA can autocatalytically self-assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points. (Figure Presented)

AB - Humpty Dumpty, heal thyself: Four fragments of a catalytic RNA can autocatalytically self-assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points. (Figure Presented)

KW - Autocatalysis

KW - Origin of life

KW - Ribozymes

KW - RNA

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/54249138520

U2 - 10.1002/anie.200802177

DO - 10.1002/anie.200802177

M3 - Article

C2 - 18780409

SN - 1433-7851

VL - 47

SP - 8424

EP - 8428

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

ER -

Systems chemistry on ribozyme self-construction: Evidence for anabolic autocatalysis in a recombination network

Abstract

Keywords

EGS Disciplines

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