The Expression Patterns of Minor Fibrillar Collagens During Development in Zebrafish

Ming Fang, Jason S. Adams, B. Lane Memahhan, Raquel J. Brown, Julia Oxford

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely serve additional functions. The minor fibrillar collagens include collagens type V and type XI. Mutations of collagen type V and XI can cause Ehlers Danlos, Stickler's, and Marshall's syndromes in human. We have characterized the spatiotemporal expression patterns of Col11a1, Col11a2, Col5a1 as well as Col5a3 in zebrafish embryos by in situ hybridization. Col5a1 is expressed in developing somites, neural crest, the head mesenchyme, developing cranial cartilage, pharyngeal arches and vertebrae. Col5a3 is detected in the notochord, mesenchyme cells in the eyes and lens. Both Col11a1 and Col11a2 have similar expression patterns, including notochord, otic vesicle, and developing cranial cartilages. Zebrafish may therefore serve as a valuable vertebrate model system for the study of diseases associated with collagens type V and XI mutations.

Original languageAmerican English
JournalBiomolecular Research Institute Publications and Presentations
DOIs
StatePublished - 1 Oct 2010

Keywords

  • Danio rerio
  • development
  • in situ hybridization
  • minor fibrillar collagens
  • zebrafish

EGS Disciplines

  • Molecular Biology

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