TY - JOUR
T1 - Tolerance and sensitization to chronic and subchronic oral caffeine
T2 - Effects of wheelrunning in rats
AU - Meliska, C. J.
AU - Landrum, R. E.
AU - Landrum, T. a.
PY - 1990/2
Y1 - 1990/2
N2 - Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.
AB - Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.
KW - Caffeine
KW - Chronic administration
KW - Subchronic administration
KW - Wheelrunning
UR - http://www.scopus.com/inward/record.url?scp=0025054995&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(90)90189-O
DO - 10.1016/0091-3057(90)90189-O
M3 - Article
C2 - 2320659
AN - SCOPUS:0025054995
SN - 0091-3057
VL - 35
SP - 477
EP - 479
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -