Tolerance and sensitization to chronic and subchronic oral caffeine: Effects of wheelrunning in rats

C. J. Meliska; R. E. Landrum; T. a. Landrum

doi:10.1016/0091-3057(90)90189-O

Tolerance and sensitization to chronic and subchronic oral caffeine: Effects of wheelrunning in rats

C. J. Meliska
, R. E. Landrum
, T. a. Landrum

Psychological Science Department

Southern Illinois University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.

Original language	English
Pages (from-to)	477-479
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(90)90189-O
State	Published - Feb 1990

Keywords

Caffeine
Chronic administration
Subchronic administration
Wheelrunning

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10.1016/0091-3057(90)90189-O

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title = "Tolerance and sensitization to chronic and subchronic oral caffeine: Effects of wheelrunning in rats",

abstract = "Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.",

keywords = "Caffeine, Chronic administration, Subchronic administration, Wheelrunning",

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AU - Landrum, R. E.

AU - Landrum, T. a.

PY - 1990/2

Y1 - 1990/2

N2 - Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.

AB - Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration.

KW - Caffeine

KW - Chronic administration

KW - Subchronic administration

KW - Wheelrunning

UR - https://www.scopus.com/pages/publications/0025054995

U2 - 10.1016/0091-3057(90)90189-O

DO - 10.1016/0091-3057(90)90189-O

M3 - Article

C2 - 2320659

AN - SCOPUS:0025054995

SN - 0091-3057

VL - 35

SP - 477

EP - 479

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 2

ER -

Tolerance and sensitization to chronic and subchronic oral caffeine: Effects of wheelrunning in rats

Abstract

Keywords

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